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Author Manley, James L., speaker.

Title Polyadenylation of mRNA precursors : mechanism, regulation and connections with other cellular processes / James L. Manley.

Published London : Henry Stewart Talks, 2007.


Location Call No. Status
Physical description 1 streaming video file (47 minutes) : digital, mono, SWF file, sound, colour.
polychrome rdacc
Series From DNA to proteins : the multiple levels of regulation.
Henry Stewart talks. Biomedical & life sciences collection. From DNA to proteins : the multiple levels of regulation.
Notes Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents Contents: Polyadenylation of mRNA precursors -- The polyadenylation machinery -- A surprising complexity in PAP -- Hyperphosphorylation by MPF inhibits PAP activity -- Gld-2 in cytoplasmic polyadenylation in oocytes -- The polyadenylation machinery -- CPSF-73 is the 3' processing endonuclease -- CPSF-73 is absent in cytoplasmic polyadenylation -- CstF protein interactions -- Regulation of gene expression by alternative polyadenylation -- The C-terminal domain of RNAPII -- The CTD can stimulate 3' cleavage in vitro -- CPSF links transcription and 3' end formation -- RNA15 crosslinks to promoters -- Polyadenylation and links to other cellular processes -- CstF-50 -- BRCA1 -- BARD1 -- BRCA associated ring domain protein -- Why does BARD1 inhibit 3' processing? -- DNA damage inhibits 3' processing -- How does BARD1 inhibit 3' processing? -- BRCA1/BARD1 target RNAPII for ubiquitination -- Many factors constitute the mRNA 3' end formation machinery.
Restrictions Access restricted to subscribers.
System notes Mode of access: World Wide Web.
System requirements: Operating System: PC Windows 2000+, Mac OSX+ 3.2. Browser Compatibility: IE6+, Firefox 2+, Opera 9+, Safari 2+ 3.3. Browser settings: enable JavaScript, enable popups from the Henry Stewart Talks site. 3.4. Required Browser Plugins & Viewers: Adobe (Macromedia) Flash Player 7+, Adobe Acrobat Reader 6.0+.
Variant Title Title on publisher web site: mRNA modifications : PolyA addition.
Polyadenylation of messenger RNA precursors : mechanism, regulation and connections with other cellular processes.