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Title The human gut-liver-axis in health and disease / Aleksander Krag, Torben Hansen, editors.

Published Cham : Springer, ©2019.


Location Call No. Status
Physical description 1 online resource (296 pages)
Series Springer Medicine eBooks 2019 English+International
Contents Intro; Acknowledgments; Contents; About the Editors; Part I: Clinical Aspects of Fatty Liver Disease; 1: Clinical Aspects of Alcoholic Liver Disease; 1.1 The Burden of Alcoholic Liver Disease; 1.2 Natural History of Alcoholic Liver Disease; 1.2.1 Simple Steatosis; 1.2.2 Steatohepatitis; 1.2.3 Liver Fibrosis; 1.2.4 Cirrhosis; 1.2.5 Timely Identification and Intervention for Alcoholic Liver Disease; 1.3 Clinical Unmet Needs; 1.3.1 Natural History; 1.3.2 Pathophysiology; 1.3.3 Non-invasive Markers; 1.3.4 Treatment Options; 1.3.5 Implementation; 1.4 The Gut-Liver Cross Talk.
1.5 A Hypothesis of the Pathogenesis of Alcoholic Liver Disease1.5.1 Gut Microbiome in Alcoholic Liver Disease; 1.5.2 Gut Barrier Function in Alcohol Liver Disease; 1.5.3 The Toxic Effect of Alcohol; 1.5.4 The Immune System in Alcoholic Liver Disease; 1.5.5 Bile Acids and Alcoholic Liver Disease; 1.6 From Hypothesis to Understanding; 1.7 Interventions Targeting the Gut to Treat Alcoholic Fatty Liver Disease; 1.7.1 Antibiotics; 1.7.2 Probiotics, Prebiotics and Synbiotics; 1.7.3 Faecal Microbiome Transplantation; 1.7.4 Adsorbants; 1.7.5 Bile Acid Modulators; 1.8 Conclusion.
2.5.2 Non-invasive Detection of Liver Steatosis and Inflammation2.5.3 Non-invasive Detection of Liver Fibrosis; 2.5.4 Liver Biopsy: Who and Why; 2.6 Histological Characteristics and Scoring Systems; 2.6.1 Fibrosis; 2.7 Natural History of NAFLD; 2.7.1 Liver Related Disease Risk; 2.7.2 Cardiovascular Disease Risk; 2.8 Treatment of NAFLD; 2.8.1 Lifestyle Intervention; 2.8.2 Pharmacological Treatment; 2.9 Conclusion; References; 3: Impact of Childhood Obesity in Fatty Liver Disease; 3.1 BMI; 3.2 Tracking; 3.3 Body Composition; 3.4 Causes of Childhood Obesity.
3.5 Ectopic Fat in the Liver3.6 Assessment of Ectopic Fat in the Liver; 3.7 Treatment of Ectopic Fat in the Liver; 3.8 Treatment of Children with Obesity; References; 4: Fetal Programming of Fatty Liver Disease; 4.1 Introduction; 4.2 Fetal Programming of Adult Disease; 4.3 Mechanisms of Fetal Programming; 4.4 Fatty Liver Disease; 4.5 Fetal Programming of Fatty Liver Disease; 4.5.1 Fetal Undernutrition and Hepatic Fat Accumulation; 4.5.2 Fetal Overnutrition and Hepatic Fat Accumulation; 4.6 Programming of NAFLD by Epigenetic Mechanisms; 4.6.1 DNA Methylation.
Bibliography References2: Adult Non-alcoholic Fatty Liver Disease (NAFLD) ; 2.1 Introduction; 2.2 Definition and Aspects of NAFLD; 2.3 Risk Factors for Development of NAFLD and Concomitant Metabolic Disorders in NAFLD; 2.3.1 Obesity and Visceral Adiposity; 2.3.2 Insulin Resistance and Metabolic Syndrome; 2.3.3 Genetics, Age and Ethnicity; 2.4 NAFLD Pathophysiology; 2.4.1 Hepatic Steatosis and Lipotoxicity; 2.4.2 Adipose Tissue Inflammation and Dysfunction; 2.4.3 Gut Microbiota and Gut-Liver Axis; 2.5 Diagnosis of NAFLD; 2.5.1 Who to Screen for NAFLD and Why Diagnose NAFLD.
Notes 4.6.2 Histone Modifications.
Includes index.
Other author Krag, Aleksander.
Hansen, Torben.
SpringerLink issuing body.
Subject Liver -- Diseases.
Gastrointestinal system -- Microbiology.
Electronic books.
ISBN 9783319988900 (electronic bk.)
3319988905 (electronic bk.)