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Author Nicholls, David G.

Title Bioenergetics 3 / David G. Nicholls and Stuart J. Ferguson.

Published Boston : Academic Press, 2002.

Copies

Location Call No. Status
 UniM BioMed  572.43 NICH    AVAILABLE
Edition 3rd ed.
Physical description 297 pages : illustrations (some colour) ; 25 cm
Notes Includes index.
Contents 1 Chemiosmotic Energy Transduction 3 -- 1.2 Chemiosmotic theory: fundamentals 3 -- 1.3 Basic morphology of energy-transducing membranes 7 -- 2 Ion Transport Across Energy-Conserving Membranes 17 -- 2.2 Classification of ion transport 17 -- 2.3 Bilayer-mediated transport 21 -- 2.4 Protein-catalysed transport 25 -- 2.5 Swelling and the co-ordinate movement of ions across membranes 26 -- 3 Quantitative Bioenergetics: the Measurement of Driving Forces 31 -- 3.2 Gibbs energy and displacement from equilibrium 33 -- 3.3 Oxidation-reduction (redox) potentials 40 -- 3.4 Ion electrochemical potential differences 46 -- 3.5 Photons 47 -- 3.6 Bioenergetic interconversions and thermodynamic constraints on their stoichiometries 48 -- 3.7 Equilibrium distributions of ions, weak acids and weak bases 50 -- 3.8 Membrane potentials, diffusion potentials, Donnan potentials and surface potentials 52 -- 4 Chemiosmotic Proton Circuit 57 -- 4.2 Measurement of protonmotive force 59 -- 4.3 Stoichiometry of proton extrusion by the respiratory chain 66 -- 4.4 Stoichiometry of proton uptake by the ATP synthase 68 -- 4.5 Proton current and respiratory control 69 -- 4.6 Proton conductance 73 -- 4.7 Mitochondrial respiration rate and metabolic control analysis 77 -- 4.8 Overall parameters of energy transduction 81 -- 4.9 Reversed electron transfer and the proton circuit driven by ATP hydrolysis 83 -- 4.10 ATP synthesis driven by an artificial protonmotive force 85 -- 4.11 Kinetic competence of [Delta]p in the proton circuit 86 -- 4.12 Light-dependent ATP synthesis by bovine heart ATP synthase 87 -- 5 Respiratory Chains 89 -- 5.2 Components of the mitochondrial respiratory chain 89 -- 5.3 Sequence of redox carriers in the respiratory chain 95 -- 5.4 Mechanism of electron transfer 99 -- 5.5 Proton translocation by the respiratory chain: 'loops', 'conformation pumps' or both? 105 -- 5.6 Complex I (NADH-UQ oxidoreductase) 107 -- 5.7 Delivering electrons to ubiquinone without proton translocation 111 -- 5.8 Ubiquinone and complex III (bc[subscript 1] or UQ-cyt c oxidoreductase) 114 -- 5.9 Cytochrome c and complex IV (cytochrome c oxidase; ferrocytochrome c: O[subscript 2] oxidoreductase) 119 -- 5.10 Overall proton and charge movements catalysed by the respiratory chain: correlation with the P/O ratio 126 -- 5.11 Superoxide production by complexes I and III 127 -- 5.12 Oxidative stress 129 -- 5.13 Nicotinamide nucleotide transhydrogenase 130 -- 5.14 Electron transport in mitochondria of non-mammalian cells 131 -- 5.15 Bacterial respiratory chains 134 -- 6 Photosynthetic Generators of Protonmotive Force 157 -- 6.2 Light reaction of photosynthesis in Rhodobacter sphaeroides and related organisms 159 -- 6.3 Generation by illumination or respiration of [Delta]p in photosynthetic bacteria 168 -- 6.4 Electron-transfer and light-capture pathway in green plants and algae 171 -- 6.5 Bacteriorhodopsin and halorhodopsin 186 -- 7 ATP Synthase 195 -- 7.2 F[subscript 1] and F[subscript o] 195 -- 7.3 Subunits of the F[subscript 1].F[subscript o]-ATPase 198 -- 7.4 Structure of F[subscript 1].F[subscript o] 199 -- 7.5 Enzymology of ATP synthase 204 -- 7.6 Relating the structure to function for ATP synthase 210 -- 7.7 Non-thermodynamic regulation of the ATP synthase 216 -- 7.8 Proton translocation by other ATPases and pyrophosphatases 216 -- 8 Metabolite and Ion Transport 219 -- 8.2 Mitochondrial cation transporters 220 -- 8.3 Mitochondrial metabolite transporters 225 -- 8.4 Transfer of electrons from cytoplasmic NADH to the respiratory chain 229 -- 8.5 Phosphate and adenine nucleotide transporters 230 -- 8.6 Uncoupling protein family 232 -- 8.7 Bacterial transport 234 -- 8.8 Transport (movement) of bacterial cells 246 -- 8.9 Transport of macromolecules across bacterial membranes 247 -- 9 Mitochondria in the Cell 249 -- 9.2 Monitoring [Delta psi subscript m] and ATP synthesis in intact cells 251 -- 9.3 Mitochondria and cellular Ca[superscript 2+] homeostasis 255 -- 9.4 Mitochondria and programmed cell death 258 -- 9.5 Mitochondria and necrotic cell death 261 -- 9.6 Mitochondrial genome 263 -- 9.7 Import and assembly of mitochondrial proteins 264 -- 9.8 Mitochondrial genetic diseases 266 -- 9.9 Mitochondrial involvement in neurodegenerative diseases 268 -- Appendix Protein structures 283.
Summary This new edition of Bioenergetics presents a clear and up-to-date explanation of the chemiosmotic theory and covers mitochondria, bacteria, and chloroplasts. Every chapter has been extensively revised and updated and a new chapter on the study of the bioenergetics of mitochondria in the intact cell is included to satisfy the enormous interest in this topic. Written for students and researchers alike, this book is the most current text on the chemiosmotic theory and membrane bioenergetics available.
Other author Ferguson, Stuart J. (Stuart John), 1949-
Subject Bioenergetics.
Biological transport, Active.
Variant Title Bioenergetics three.
ISBN 0125181213