My Library

University LibraryCatalogue

For faster,
simpler
access.
Use Lean
Library.
Get it now
Don't show me again

LEADER 00000cam a2200685Ii 4500 
003    OCoLC 
005    20190319060704.9 
006    m     o  d         
007    cr cnu|||unuuu 
008    180502s2018    sz      ob    000 0 eng d 
015    GBB8K7324|2bnb 
019    SpringerEBAon1033604009 
020    9783319757322|q(electronic bk.) 
020    3319757326|q(electronic bk.) 
020    |z9783319757315|q(print) 
020    |z3319757318 
024 7  10.1007/978-3-319-75732-2|2doi 
037    com.springer.onix.9783319757322|bSpringer Nature 
040    N$T|beng|erda|epn|cN$T|dGW5XE|dEBLCP|dN$T|dAZU|dYDX|dUPM
       |dCOO|dUAB|dOCLCF|dMERER|dOCLCQ|dU3W|dYDX|dSTF|dCNCEN
       |dOCLCQ|dWYU|dOCLCQ|dLVT|dUKMGB|dDKU|dCAUOI|dBRX|dCEF 
049    MAIN 
050  4 RS420|b.K38 2018 
066    |c(Q 
082 04 615.1/900285|223 
100 1  Kaushik, Aman Chandra,|eauthor. 
245 10 Bioinformatics techniques for drug discovery :
       |bapplications for complex diseases /|cAman Chandra 
       Kaushik, Ajay Kumar, Shiv Bharadwaj, Ravi Chaudhary, 
       Shakti Sahi. 
264  1 Cham, Switzerland :|bSpringer,|c[2018] 
300    1 online resource. 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
347    text file|bPDF|2rda 
490 1  SpringerBriefs in computer science,|x2191-5768 
504    Includes bibliographical references. 
505 0  Intro; Preface; Contents; About the Authors; 1 Brief 
       Introduction; 1.1 Brief Evolutionary History of In Silico 
       Approaches; 1.2 Computational Drug Discovery and Design; 
       1.3 Epigenetics: Beyond the Sequence; 1.4 Histones 
       Modification; References; 2 Ligand-Based Approach for In-
       silico Drug Designing; 2.1 Introduction; 2.2 Molecular 
       Descriptors; 2.2.1 2D QSAR Descriptors; 2.2.2 3D QSAR 
       Descriptors; 2.2.3 Multidimensional QSAR; 2.3 
       Constitutional Descriptors; 2.4 Quantitative Structure-
       Activity Relationships; 2.5 Molecular Fingerprint and 
       Similarity Searches; 2.6 Similarity Searches in LB-CADD. 
505 8  2.7 Similarity Networks and off Target Predictions2.8 
       Fingerprint Extensions; 2.9 Computational Methods for 
       Biomolecular Docking; References; 3 Structure-Based 
       Approach for In-silico Drug Designing; 3.1 Introduction; 
       3.2 Protein Docking; 3.2.1 Protein-Protein Docking; 3.2.2 
       Protein-Ligand Docking; References; 4 Three-Dimensional 
       (3D) Pharmacophore Modelling-Based Drug Designing by 
       Computational Technique; 4.1 Introduction; 4.1.1 
       Pharmacophore Model; References; 5 Molecular Dynamics 
       Simulation Approach to Investigate Dynamic Behaviour of 
       System Through the Application of Newtonian Mechanics. 
505 8  5.1 Introduction5.2 Molecular Dynamics Simulations; 5.3 
       Monte Carlo Research with Metropolis Criterion; 
       References; 6 Receptor Thermodynamics of Ligand-Receptor 
       or Ligand-Enzyme Association; 6.1 Introduction; 6.2 
       Database Searching; 6.2.1 De Novo Drug Design; 6.3 State-
       of-the-Art Free Energy Calculations; References; 7 
       Thermodynamic Cycles and Their Application in Protein 
       Targets; 7.1 Introduction; 7.2 Protein Targets and 
       Applications; 7.3 4-Hydroxyphenylpyruvate Dioxygenase 
       (HPPD); 7.4 Oligopeptide-Binding Protein a (OppA); 
       References; 8 Genomics and Proteomics Using Computational 
       Biology. 
505 8  8.1 Introduction8.2 Peptide Identification; 8.3 De Novo 
       and Hybrid Algorithms; 8.4 Sequence Database Search 
       Algorithms; 8.5 Scoring of Peptide Identifications; 8.6 
       Peptide-Spectrum Match Scores and Common Thresholds; 8.7 
       Fundamentals of Gene Transcription and Translation; 8.8 
       Genome Sequencing; 8.9 Definition of Genome Annotation; 
       8.10 Genome Annotation Strategies; 8.11 Proteogenomics; 
       References. 
520    The application of bioinformatics approaches in drug 
       design involves an interdisciplinary array of 
       sophisticated techniques and software tools to elucidate 
       hidden or complex biological data. This work reviews the 
       latest bioinformatics approaches used for drug discovery. 
       The text covers ligand-based and structure-based 
       approaches for computer-aided drug design, 3D 
       pharmacophore modeling, molecular dynamics simulation, the
       thermodynamics of ligand-receptor and ligand-enzyme 
       association, thermodynamic characterization and 
       optimization, and techniques for computational genomics 
       and proteomics. 
650  0 Drugs|xDesign|xData processing. 
650  0 Bioinformatics. 
650  0 Pharmacy informatics. 
655  0 Electronic book. 
655  4 Electronic books. 
700 1  Kumar, Ajay,|eauthor. 
700 1  Bharadwaj, Shiv,|eauthor. 
700 1  Chaudhary, Ravi,|eauthor. 
700 1  Sahi, Shakti,|eauthor. 
710 2  SpringerLink|eissuing body. 
776 08 |iPrinted edition:|z9783319757315 
830  0 SpringerBriefs in computer science. 
830  0 Springer Computer Science eBooks 2018 English+
       International 
856 40 |uhttps://ezp.lib.unimelb.edu.au/login?url=http://
       link.springer.com/10.1007/978-3-319-75732-2|zConnect to 
       ebook (University of Melbourne only) 
880    |6520-00|aThe application of bioinformatics approaches in 
       drug design involves an interdisciplinary array of 
       sophisticated techniques and software tools to elucidate 
       hidden or complex biological data. This work reviews the 
       latest bioinformatics approaches used for drug discovery. 
       The text covers ligand-based and structure-based 
       approaches for computer-aided drug design, 3D 
       pharmacophore modeling, molecular dynamics simulation, the
       thermodynamics of ligand#x98;́ѫreceptor and 
       ligand#x98;́ѫenzyme association, thermodynamic 
       characterization and optimization, and techniques for 
       computational genomics and proteomics. 
990    Springer EBA e-book collections for 2017-2019 
990    Springer Computer Science eBooks 2018 - Full Set 
990    Batch Ebook load (bud2) - do not edit, delete or attach 
       any records. 
991    |zNEW New collection springerlink.ebookscs2018 2019-03-18 
Location Call No. Status
 UniM INTERNET resource    AVAILABLE