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Book Cover
E-RESOURCE

Title Safety and efficacy of gene-based therapeutics for inherited disorders / Nicola Brunetti-Pierri, editor.

Published Cham, Switzerland : Springer, [2017]
©2017

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Location Call No. Status
 UniM INTERNET resource    AVAILABLE
Physical description 1 online resource
Series Springer Biomedical and Life Sciences eBooks 2017 English+International
Bibliography Includes bibliographical references and index.
Contents Overview: gene transfer strategies, principles, applications -- Manufacturing viral gene therapy vectors: general approaches and challenges -- Retrovirus- and lentivirus-based vectors -- Preclinical and clinical applications of retroviral vectors -- Preclinical and clinical applications of lentiviral vectors -- Retrovirus and lentivirus integration -- Adenovirus-based vectors for gene therapy -- Adenoviral vector-host interactions -- Helper-dependent adenoviral vectors -- Gene therapy for cancer treatment -- Oncolytic adenoviruses for cancer treatment -- Vaccination by gene transfer vectors -- AAV vectors: general features and applications -- Adaptive immune response to viral vector delivery -- Herpes viruses: general features and applications -- RNA interference-based strategy for treatment of human diseases -- Antisense oligonucleotide based therapeutics -- Gene editing strategies -- Nonviral vectors.
Summary In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and specifically focus on the challenges and possible solutions that researchers are testing in order to improve the safety of gene therapy for genetic diseases. This comprehensive and authoritative overview of vector development is a necessary text for researchers, toxicologists, pharmacologists, molecular biologists, physicians, and students in these fields.
Other author Brunetti-Pierri, Nicola, editor.
SpringerLink issuing body.
Subject Genetic disorders -- Gene therapy.
Genetic transformation.
Electronic books.
ISBN 9783319534572 (electronic bk.)
3319534572 (electronic bk.)
3319534556
9783319534558
9783319534558
Standard Number 10.1007/978-3-319-53457-2