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LEADER 00000cam a2200553Ii 4500 
003    OCoLC 
005    20190319055903.2 
006    m     o  d         
007    cr cnu|||unuuu 
008    180914s2018    sz a    ob    000 0 eng d 
015    GBB8H8523|2bnb 
019    SpringerEBAon1052566807 
020    9783319934853|q(electronic bk.) 
020    3319934856|q(electronic bk.) 
020    |z9783319934846 
020    |z3319934848 
020    9783319934860|q(print) 
020    3319934864 
024 7  10.1007/978-3-319-93485-3|2doi 
037    com.springer.onix.9783319934853|bSpringer Nature 
040    N$T|beng|erda|epn|cN$T|dN$T|dGW5XE|dEBLCP|dYDX|dUX0|dNLE
049    MAIN 
050  4 QP356.25|b.H86 2018 
082 04 612.8|223 
245 00 Human neural stem cells :|bfrom generation to 
       differentiation and application /|cLeonora Buzanska, 
264  1 Cham, Switzerland :|bSpringer,|c[2018] 
300    1 online resource. 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
347    text file|bPDF|2rda 
490 1  Results and problems in cell differentiation ;|v66 
504    Includes bibliographical references. 
505 0  Part I. Derivation and-or generation of human neural stem 
       cells: Derivation of neural stem cells from the developing
       and adult human brain / Claire M. Kelly and Maeve A. 
       Caldwell -- Human somatic stem cell neural differentiation
       potential / David J. Eve [and four others] -- Neural stem 
       cells derived from human-induced pluripotent stem cells 
       and their use in models of CNS injury / Pavla Jendelova, 
       Eva Sykova, and Slaven Erceg -- Generation of human neural
       stem cells by direct phenotypic conversion / Daekee Kwon, 
       Hee-Jin Ahn, and Kyung-Sun Kang -- Part II. 
       Differentiation and underlying mechanisms: Epigenetic 
       regulation of human neural stem cell differentiation / 
       Mizuki Honda, Kinichi Nakashima, and Sayako Katada -- 
       Induced pluripotent stem cells reveal common 
       neurodevelopmental genome deprograming in schizophrenia / 
       Sridhar T. Narla [and four others] -- Genome editing in 
       human neural stem and progenitor cells / Raul Bardini 
       Bressan and Steven M. Pollard -- Brain organoids : 
       expanding our understanding of human development and 
       disease / L. B. Chuye [and nine others] -- Bioengineering 
       of the human neural stem cell niche : a regulatory 
       environment for cell fate and potential target for 
       neurotoxicity / Leonora Buzanska, Marena Zychowicz, and 
       Agnieszka Kinser-Ovaskainen -- Part III. Therapeutic 
       potential of human neural stem cells: Updates on human 
       neural stem cells : from generation, maintenance, and 
       differentiation to applications in spinal cord injury 
       research / Yang D. Teng [and six others] -- Human neural 
       stem cells for ischemic stroke treatment / Zaal Kokaia and
       Vladimer Darsalia -- Modeling complex neurological 
       diseases with stem cells : a study of bipolar disorder / 
       Cameron D. Pernia [and six others] -- Neural stem cell 
       dysfunction in human brain disorders / Ewa Liszweska and 
       Jack Jaworski -- Human fetal neural stem cells for 
       neurodegenerative disease treatment / Daniela Ferrari [and
       three others]. 
520    This book summarizes early pioneering achievements in the 
       field of human neural stem cell (hNSC) research and 
       combines them with the latest advances in stem cell 
       technology, including reprogramming and gene editing. The 
       powerful potential of hNSC to generate and repair the 
       developing and adult CNS has been confirmed by numerous 
       experimental in vitro and in vivo studies. The book 
       presents methods for hNSC derivation and discusses the 
       mechanisms underlying NSC in vitro fate decisions and 
       their in vivo therapeutic mode of action. The long-
       standing dogma that the human central nervous system (CNS)
       lacks the ability to regenerate was refuted at the end of 
       the 20th century, when evidence of the presence of 
       neurogenic zones in the adult human brain was found. These
       neurogenic zones are home to human neural stem cells 
       (hNSCs), which are capable of self-renewing and 
       differentiating into neurons, astrocytes and 
       oligodendrocytes. NSCs isolated from human CNS have a 
       number of clinical advantages, especially the innate 
       potential to differentiate into functional neural cells. 
       Nevertheless, their full clinical exploitation has been 
       hindered by limited access to the tissue and low expansion
       potential. The search for an alternative to CNS sources of
       autologous, therapeutically competent hNSCs was the 
       driving force for the many studies proving the in vitro 
       plasticity of different somatic stem cells to generate 
       NSCs and their functional progeny. Now the era of induced 
       pluripotent stem cells has opened entirely new 
       opportunities to achieve research and therapeutic goals 
       with the aid of hNSCs. 
650  0 Neural stem cells. 
655  4 Electronic books. 
700 1  Buzanska, Leonora,|eeditor. 
710 2  SpringerLink|eissuing body. 
776 08 |cOriginal|z3319934848|z9783319934846|w(OCoLC)1035509912 
830  0 Results and problems in cell differentiation ;|v66. 
830  0 Springer Biomedical and Life Sciences eBooks 2018 English+
856 40 |u|zConnect to 
       ebook (University of Melbourne only) 
990    Springer EBA e-book collections for 2017-2019 
990    Springer Biomedical and Life Sciences eBooks 2018 - Full 
990    Batch Ebook load (bud2) - do not edit, delete or attach 
       any records. 
991    |zNEW New collection springerlink.ebooksbls2018 2019-03-18
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