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008 180914s2018 sz a ob 000 0 eng d
020 9783319934853|q(electronic bk.)
020 3319934856|q(electronic bk.)
024 7 10.1007/978-3-319-93485-3|2doi
037 com.springer.onix.9783319934853|bSpringer Nature
050 4 QP356.25|b.H86 2018
082 04 612.8|223
245 00 Human neural stem cells :|bfrom generation to
differentiation and application /|cLeonora Buzanska,
264 1 Cham, Switzerland :|bSpringer,|c
300 1 online resource.
338 online resource|bcr|2rdacarrier
347 text file|bPDF|2rda
490 1 Results and problems in cell differentiation ;|v66
504 Includes bibliographical references.
505 0 Part I. Derivation and-or generation of human neural stem
cells: Derivation of neural stem cells from the developing
and adult human brain / Claire M. Kelly and Maeve A.
Caldwell -- Human somatic stem cell neural differentiation
potential / David J. Eve [and four others] -- Neural stem
cells derived from human-induced pluripotent stem cells
and their use in models of CNS injury / Pavla Jendelova,
Eva Sykova, and Slaven Erceg -- Generation of human neural
stem cells by direct phenotypic conversion / Daekee Kwon,
Hee-Jin Ahn, and Kyung-Sun Kang -- Part II.
Differentiation and underlying mechanisms: Epigenetic
regulation of human neural stem cell differentiation /
Mizuki Honda, Kinichi Nakashima, and Sayako Katada --
Induced pluripotent stem cells reveal common
neurodevelopmental genome deprograming in schizophrenia /
Sridhar T. Narla [and four others] -- Genome editing in
human neural stem and progenitor cells / Raul Bardini
Bressan and Steven M. Pollard -- Brain organoids :
expanding our understanding of human development and
disease / L. B. Chuye [and nine others] -- Bioengineering
of the human neural stem cell niche : a regulatory
environment for cell fate and potential target for
neurotoxicity / Leonora Buzanska, Marena Zychowicz, and
Agnieszka Kinser-Ovaskainen -- Part III. Therapeutic
potential of human neural stem cells: Updates on human
neural stem cells : from generation, maintenance, and
differentiation to applications in spinal cord injury
research / Yang D. Teng [and six others] -- Human neural
stem cells for ischemic stroke treatment / Zaal Kokaia and
Vladimer Darsalia -- Modeling complex neurological
diseases with stem cells : a study of bipolar disorder /
Cameron D. Pernia [and six others] -- Neural stem cell
dysfunction in human brain disorders / Ewa Liszweska and
Jack Jaworski -- Human fetal neural stem cells for
neurodegenerative disease treatment / Daniela Ferrari [and
520 This book summarizes early pioneering achievements in the
field of human neural stem cell (hNSC) research and
combines them with the latest advances in stem cell
technology, including reprogramming and gene editing. The
powerful potential of hNSC to generate and repair the
developing and adult CNS has been confirmed by numerous
experimental in vitro and in vivo studies. The book
presents methods for hNSC derivation and discusses the
mechanisms underlying NSC in vitro fate decisions and
their in vivo therapeutic mode of action. The long-
standing dogma that the human central nervous system (CNS)
lacks the ability to regenerate was refuted at the end of
the 20th century, when evidence of the presence of
neurogenic zones in the adult human brain was found. These
neurogenic zones are home to human neural stem cells
(hNSCs), which are capable of self-renewing and
differentiating into neurons, astrocytes and
oligodendrocytes. NSCs isolated from human CNS have a
number of clinical advantages, especially the innate
potential to differentiate into functional neural cells.
Nevertheless, their full clinical exploitation has been
hindered by limited access to the tissue and low expansion
potential. The search for an alternative to CNS sources of
autologous, therapeutically competent hNSCs was the
driving force for the many studies proving the in vitro
plasticity of different somatic stem cells to generate
NSCs and their functional progeny. Now the era of induced
pluripotent stem cells has opened entirely new
opportunities to achieve research and therapeutic goals
with the aid of hNSCs.
650 0 Neural stem cells.
655 4 Electronic books.
700 1 Buzanska, Leonora,|eeditor.
710 2 SpringerLink|eissuing body.
776 08 |cOriginal|z3319934848|z9783319934846|w(OCoLC)1035509912
830 0 Results and problems in cell differentiation ;|v66.
830 0 Springer Biomedical and Life Sciences eBooks 2018 English+
856 40 |uhttps://ezp.lib.unimelb.edu.au/login?url=http://
ebook (University of Melbourne only)
990 Springer EBA e-book collections for 2017-2019
990 Springer Biomedical and Life Sciences eBooks 2018 - Full
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