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Title Pancreatic cancer and tumor microenvironment / edited by Paul J. Grippo, Hidayatullah G. Munshi.

Published Trivandrum, India : Transworld Research Network, 2012.


Location Call No. Status
Physical description 1 online resource : illustrations
Series NCBI BookShelf
Bibliography Includes bibliographical references.
Contents Foreward: it takes two to tango : pancreatic cancer and its microenvironment -- Pathology of pancreatic stroma in PDAC -- Imaging the pancreatic ECM -- Pancreatic stellate cells and fibrosis -- Pancreatic cancer and the tumor microenvironment: mesenchyme's role in pancreatic carcinogenesis -- Epithelial-mesenchymal transition and pancreatic cancer progression -- Pancreatic cancer stem cell and mesenchymal stem cell -- Signaling pathways mediating epithelial-mesenchymal crosstalk in pancreatic cancer: hedgehog, notch and TGF[beta] -- Desmoplasia and chemoresistance in pancreatic cancer -- Therapeutic targeting of pancreatic stroma.
Summary Pancreatic adenocarcinoma is a highly lethal disease that is histologically characterized by a dense desmoplastic reaction (DR) surrounding malignant epithelial cells. The DR is composed of extracellular matrix (ECM) proteins, fibroblasts, stellate cells, endothelial cells, immune cells, and neurons. Accumulating evidence indicates that the epithelial and stromal compartments interact to enhance the aggressive nature of this disease. Pancreatic cancer cells release various factors that stimulate the stroma. Stromal cells, in turn, release mitogenic substances that stimulate tumor growth, invasion, and resistance to therapy. As we better understand the interactions between the stromal and epithelial cell compartments in pancreatic adenocarcinoma, it is becoming evident that anticancer therapies targeting the stroma, in addition to epithelial cells, may play a key role in improving clinical outcomes for patients with this deadly disease.
Language notes English.
Other author Grippo, Paul.
Munshi, Hidayatullah G.
National Library of Medicine issuing body.
Subject Electronic books.
ISBN 9788178955483