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Title Therapeutic targets in airway inflammation / edited by N. Tony Eissa, David P. Huston.

Published New York : Marcel Dekker, [2003]


Location Call No. Status
 UniM BioMed ST  616.238 THER    AVAILABLE
Physical description xxxi, 957 pages : illustrations ; 24 cm.
Series Lung biology in health and disease ; v. 177.
Lung biology in health and disease ; v. 177.
Bibliography Includes bibliographical references and index.
Contents 1. Pathophysiology of Airway Inflammation in Asthma / Paula J. Busse, William W. Busse 1 -- 2. Primary Human Lung Cells in the Evaluation of Airway Inflammation / Tannishia M. Goggans, Serpil C. Erzurum 55 -- 3. Airway pH Homeostasis in Asthma and Other Inflammatory Lung Diseases / John Hunt, Benjamin Gaston 63 -- 4. Monitoring of Exhaled Breath to Assess Airway Inflammation in Asthma / Peter J. Barnes 81 -- 5. Modulatory Effects of Carbon Monoxide on the Inflammatory Response / Francis Whalen, Augustine M. K. Choi, Jigme M. Sethi 93 -- 6. Reactive Nitrogen Species and Tyrosine Nitration in Airway Inflammation / Albert van der Vliet, Jason P. Eiserich, Brian Morrissey, Carroll E. Cross 101 -- 7. S-Nitrosothiols in Lung Inflammation / Harvey E. Marshall, Loretta G. Que, Jonathan S. Stamler, Benjamin Gaston 123 -- 8. Contribution of Nitric Oxide Synthase Isoforms to Allergen-Induced Airway Hyperresponsiveness and Inflammation: Lessons from Murine Models / George T. De Sanctis, El-Bdaoui Haddad 143 -- 9. Molecular Mechanisms of Increased Nitric Oxide in Airway Inflammation / Weiling Xu, Serpil C. Erzurum 167 -- 10. Regulation of Nitric Oxide Synthesis by Inducible Nitric Oxide Synthase / Pawel Kolodziejski, N. Tony Eissa 181 -- 11. Novel Strategies for Selective Inhibition of Inducible Nitric Oxide Synthase / John F. Parkinson 199 -- 12. Leukocyte Recruitment in Allergic Pulmonary Inflammation / Bruce S. Bochner 223 -- 13. Neutrophil Emigration in the Lungs / Claire M. Doerschuk 249 -- 14. Dendritic Cells / A. Karolina Palucka, Jacques Banchereau 281 -- 15. Roles of Mast Cells in Airway Hyperreactivity, Inflammation and Remodeling, and Immunoregulation in Asthma / John L. Faul, Stephen J. Galli 299 -- 16. Mast Cell Exocytosis in Airway Inflammation / Roberto Adachi, Rupesh Nigam, Burton F. Dickey 327 -- 17. Mast Cell Proteases / Kenneth C. Fang, George H. Caughey 349 -- 18. Peroxidases and Asthma / Michael E. Greenberg, Stanley L. Hazen 373 -- 19. Chemokines in Allergic Airway Inflammation / Rafeul Alam 397 -- 20. Role of the Eotaxin Subfamily of Chemokines in Allergic Eosinophilic Inflammation / Nives Zimmermann, Marc E. Rothenberg 421 -- 21. Interleukin-4 and Interleukin-13 in Human and Experimental Asthma / David B. Corry 465 -- 22. Interleukin-5 and Eosinophils as Therapeutic Targets for the Treatment of Asthma / Paul S. Foster 479 -- 23. Modulating the Interleukin-5 Response in Asthma / Jennifer C. Huang, Margarita Martinez-Moczygemba, Anthony P. Nguyen, David P. Huston 495 -- 24. Role of Interleukin-9 in Allergic Inflammation of Asthma / Ulla-Angela Temann, Richard A. Flavell 519 -- 25. Epithelial Production of IL-12 p80 During Viral Infection and Asthma Supports an Altered Paradigm for Airway Inflammation / Michael J. Walter, Michael J. Holtzman 535 -- 26. Interleukin-16 and Airway Hyperresponsiveness in Asthma / Frederic F. Little, William W. Cruikshank, David M. Center 563 -- 27. Modulation of the Allergic Response: The Role of IL-18 / David M. Walter, Rosemarie H. DeKruyff, Dale T. Umetsu 581 -- 28. Inhibition of Cytokine Signaling / Arnob Banerjee, Miera B. Harris, Paul Rothman 599 -- 29. Eicosanoids as Mediators and Therapeutic Targets in Airway Inflammation / Marc Peters-Golden 627 -- 30. Nitric Oxide, Reactive Nitrogen Species, and Lipid Mediator Generation in the Lung / James R. Copeland, Mark T. Gladwin, James H. Shelhamer 657 -- 31. Adenosine Signaling and Lung Inflammation / Suman K. Banerjee, Michael R. Blackburn 681 -- 32. Complement Factor 5 in Asthma / Marsha Wills-Karp, Jorg Kohl, Christopher L. Karp 699 -- 33. Complement Anaphylatoxin Receptors in Asthma / Norma P. Gerard, Craig Gerard 715 -- 34. Inflammatory and Structural Changes in Airway Remodeling of Asthma / Anthony E. Redington, Stephen T. Holgate 723 -- 35. Role of Proteases in Airway Remodeling / Farrah Kheradmand, Kirtee Rishi 749 -- 36. Airway Smooth Muscle: An Immunomodulatory Cell? / Aili L. Lazaar, Reynold A. Panettieri, Jr. 767 -- 37. Cellular Trafficking of [beta subscript 2]-Adrenergic Receptors / Robert H. Moore, Brain J. Knoll 781 -- 38. Genetic Targets in Asthma / Arjun B. Chatterjee, Timothy D. Howard, Eugene R. Bleecker 797 -- 39. Application of Pharmacogenetics to the Therapeutics of Asthma / Eric S. Silverman, Josephine Hjoberg, Lyle J. Palmer, Kelan Tantisira, Scott T. Weiss, Jefffrey M. Drazen 823 -- 40. DNA-Based Immunotherapy for Asthma / David H. Broide, Eyal Raz 839 -- 41. Allergen Immunotherapy: Therapeutic Vaccines for Allergic Diseases / Jean Bousquet, Pascal Demoly, Antonio M. Vignola 867 -- 42. Peptide-Based Therapy for Asthma / A. Barry Kay, F. Runa Ali, Mark Larche 891 -- 43. Reducing IgE Levels as a Strategy for the Treatment of Asthma / John V. Fahy 907 -- 44. Strategies to Reduce Excessive Mucus Secretion in Airway Inflammation / Christopher Evans, Anurag Agrawal, Burton F. Dickey 923.
Summary This reference examines the cellular, molecular, and genetic mechanisms involved in airway inflammation, as well as the pathophysiology, epidemiology, and etiology of asthma -- exploring strategies to prevent cellular injury and oxidative tissue damage, inhibit key inflammatory pathways, and identify disease-specific targets to reduce the induction, progression, and exacerbation of disease. Presenting methods to assess the efficacy of anti-inflammatory treatments, indicate high-risk groups, and develop more efficient markers of control loss and deterioration in asthma, Therapeutic Targets in Airway Inflammation discusses the pathophysiology of airway inflammation in asthma...the genetics of asthma...the function of carbon monoxide, reactive nitrogen species, tyrosine nitration, and S-nitrosothiols in airway inflammation...the role of cytokines, adhesion molecules, and chemokines in allergic reactions...eicosanoids and lipid mediators in asthma...adenosine signaling in lung inflammation...airway remodeling...the regulation of various nitric oxide synthase isoforms in the airway...and novel treatment strategies for asthma.
Other author Huston, David P.
Eissa, N. Tony.
Subject Asthma -- Pathophysiology.
Asthma -- Etiology.
Airway (Medicine)
Asthma -- Chemotherapy.
Asthma -- Immunotherapy.
ISBN 082470956X