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Book Cover
Author Karschau, Jens, author.

Title Mathematical modelling of chromosome replication and replicative stress / Jens Karschau.

Published Cham : Springer, [2014]


Location Call No. Status
Physical description 1 online resource (xiii, 76 pages) : illustrations (some color).
Series Springer Theses, 2190-5053
Springer theses, 2190-5053
Springer English/International eBooks 2015 - Full Set
Notes "Doctoral thesis accepted by the University of Aberdeen, UK."
Bibliography Includes bibliographical references.
Contents Supervisor's Foreword; Abstract; Acknowledgments; Contents; List of Publications; 1 Introduction; 1.1 The Cell Cycle; 1.2 General Principles of the DNA Replication Process; 1.3 Aims of This Thesis; 1.4 Origin Licensing; 1.5 Origin Firing During DNA Synthesis; 1.6 Replication Timing, Origin Positioning, and the Random Completion Problem; 1.7 Mathematical Modelling of DNA Replication; 1.8 The Spatio-Temporal Organisation of Replication Forks; References; 2 Optimal Origin Placement for Minimal Replication Time; [DELETE]; 2.1 Properties of Origins of Replication in Saccharomyces cerevisiae.
2.2 A Mathematical Model for Optimal Origin Positions2.2.1 A Simplified Two Origin Model; 2.2.2 Many Origin Loci; 2.2.3 Evolutionary Pressure Drives Yeast Origin Loci to Optimal Positions; 2.2.4 Loci Competence and Circular Chromosomes; 2.3 Optimal Origin Loci and Stochasticity in Origin Activation Time; 2.4 Summary; References; 3 Actively Replicating Domains Randomly Associate into Replication Factories; [DELETE]; 3.1 Summary of Experimental Procedure; 3.2 The Diffusion Time Scale of Two Replicating Dots; 3.3 Binding Energy; 3.4 Test of the Analytical Result Versus Computer Simulations.
3.5 Fit to Experimental Data of Replisome Association3.6 Genome-Wide Replication Data and the Number of Forks Per Factory; 3.7 Summary; References; 4 Summary and Conclusions; [DELETE].
Summary DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive. This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome and how is the spatial orga.
Other author SpringerLink issuing body.
Subject DNA replication -- Mathematical models.
Electronic books.
ISBN 9783319088617
Standard Number 10.1007/978-3-319-08861-7