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Book Cover
Author Hanke, Wolfgang, author.

Title Gravitational biology. II, Interaction of gravity with cellular components and cell metabolism / Wolfgang Hanke, Florian P.M. Kohn, Maren Neef, Rüdiger Hampp.

Published Cham : Springer, 2018.


Location Call No. Status
Physical description 1 online resource (xiv, 94 pages)
Series SpringerBriefs in space life sciences
SpringerBriefs in space life sciences.
Springer Biomedical and Life Sciences eBooks 2018 English+International
Notes Description based upon print version of record.
Contents Intro; Preface to the Series; Preface; Acknowledgements; Contents; Chapter 1: Interaction of Gravity with Cellular Compounds; 1.1 Introduction; 1.2 Structure and Function of the Neuronal System; 1.3 Biological Membranes; 1.4 Neuronal Cells; 1.5 Thermodynamics of Neuronal Systems; 1.6 Interaction of Gravity with Single Molecules; 1.7 Interaction of Gravity with Membranes; 1.8 Interaction of Gravity with Neuronal Cells; 1.9 Membrane Potential; 1.10 Action Potentials; 1.11 Cytosolic Calcium Concentration; 1.12 Discussion and Consequences; 1.13 Modeling the Gravity Dependence of Neuronal Tissue
1.14 Space Pharmacology1.15 Outlook and Future Perspectives; References; Chapter 2: Interaction of Gravity with Cell Metabolism; 2.1 Introduction; 2.2 Methods; 2.2.1 Opportunities for Exposure; Centrifugation; Clinorotation; Random Positioning; Magnetic Levitation; Space Shuttle and Satellite; Sounding Rockets; Parabolic Flights: Hyper-g, Partial g, and Microgravity; 2.2.2 Plant Material; 2.2.3 Determination of Key Metabolites; 2.2.4 Metabolic Labeling with (14C)-Glucose; 2.2.5 Real-Time Analysis of Ca2+ and Hydrogen Peroxide
2.2.6 Gene and Protein Expression2.3 Results; 2.3.1 Metabolism; 2.3.2 Secondary Messengers: Calcium and Hydrogen Peroxide; 2.3.3 Gene Expression; Expression of Genes Coding for Primary Metabolism; Expression of Genes Coding for Transcription Factors; Time-Course Experiments: Hyper-g and Simulation of Microgravity; Effects of Microgravity: MAXUS 7; Functions of TFs; Conclusion for Transcription Factor Studies; 2.3.4 Array Studies; Macroarrays (̀̀Home Made)́́; Early Microarrays (Incyte Genomics); Affymetrix Microarrays; 2.3.5 Platforms
2.3.6 Protein Expression and Modulation2.3.6.1 Hypergravity; 2-D Clinorotation; Random Positioning; Phosphoproteom; Two-dimensional SDS Polyacrylamide Gel Electrophoresis; Protein Labeling; Evaluation of Simulation of Microgravity; How We Think that a Gravity-Related Line of Plant Responses Works: Secondary Messengers, Genes, and Proteins; ROS Scavenging and Detoxifying Enzymes; Signal Transduction; Metabolism; Protein Translation and Proteolysis; Cell Wall Biosynthesis; Ion homeostasis; 2.4 Conclusions; References
Summary This volume of the series Space Life Sciences provides insights into the latest findings of gravity research and the effect of gravity on biological systems, specifically on a cellular and molecular level. It starts by explaining the underlying physics of gravity and presenting some novel ideas on the basic principles of gravity perception. It then goes on to discuss how, in response to gravity perception, secondary messengers such as calcium and hydrogen peroxide, might control responses further downstream, like gene and protein expression and modulation. Further, it describes the consequences for animal and plant cells as well as for metabolism. Written by experts in the field, this book is a valuable resource for students and researchers in biochemistry, medicine and biomedicine, wanting to gain a solid understanding of membrane biology, secondary messenger function and gene and protein expression, specifically in the context of gravity.
Other author Kohn, Florian P. M., author.
Neef, Maren, author.
Hampp, Rüdiger, author.
SpringerLink issuing body.
Subject Gravity -- Physiological effect.
Biotechnological microorganisms.
Electronic books.
ISBN 9783030005962 (electronic bk.)
3030005968 (electronic bk.)
Standard Number 10.1007/978-3-030-00596-2