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Title Viral proteins counteracting host defenses [electronic resource] / edited by U.H. Koszinowski and H. Hengel.

Published Berlin ; New York : Springer, ò002.


Location Call No. Status
Physical description 1 online resource (x, 325 pages) : illustrations.
Series Current topics in microbiology and immunology, 0070-217X ; 269
Current topics in microbiology and immunology ; 269.
Bibliography Includes bibliographical references and index.
Contents Strategies for the Identification and Analysis of Viral Immune-Evasive Genes -- Cytomegalovirus as an Example / A. Gutermann, A. Bubeck, M. Wagner, U. Reusch, C. Menard, U.H. Koszinowski -- Avoiding Proteasomal Processing: The Case of EBNA1 / N.P. Dantuma, A. Sharipo, M.G. Masucci -- The HCMV Gene Products US2 and US11 Target MHC Class I Molecules for Degradation in the Cytosol / F.J. van der Wal, M. Kikkert, E. Wiertz -- Corking the Bottleneck: The Transporter Associated with Antigen Processing as a Target for Immune Subversion by Viruses / F. Momburg, H. Hengel -- Herpes Viral Proteins Manipulating the Peptide Transporter TAP / E. Reits, A. Griekspoor, J. Neefjes -- Herpes Viral Proteins Blocking the Transporter Associated with Antigen Processing TAP -- From Genes to Function and Structure / D. Bauer, R. Tampe -- Inhibition of the MHC Class II Antigen Presentation Pathway by Human Cytomegalovirus / D.C. Johnson, N.R. Hegde -- Viral Evasion of Natural Killer Cells During Human Cytomegalovirus Infection / V.M. Braud, P. Tomasec, G.W.G. Wilkinson -- Function of CMV-Encoded MHC Class I Homologues / H.E. Farrell, N.J. Davis-Poynter, D.M. Andrews, M.A. Degli-Esposti -- Human Cytomegalovirus Inhibition of Major Histocompatibility Complex Transcription and Interferon Signal Transduction / D.M. Miller, C.M. Cebulla, D.D. Sedmak -- Counteraction of Interferon-Induced Antiviral Responses by Herpes Simplex Viruses / D.A. Leib.
Restrictions Use copy Restrictions unspecified star MiAaHDL
Reproduction Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010. MiAaHDL
Summary Viruses that establish long-term or even lifelong infections have evolved sophisticated strategies to counteract a powerful host immune response. Bringing large DNA viruses like adenoviruses and herpesviruses into focus, this book documents a variety of such mechanisms, indicating a very active area of research over the last few years. The repertoire of viral mechanisms interfering with immune functions includes proteins that target antigen presentation pathways to prevent immune recognition or molecules mimicking soluble mediators ("virokines") or chemokine receptors. In view of the highly redundant immune effector mechanisms, the viral functions can teach us the relative biological significance of host defense strategies. Selected and optimized during evolution, the viral inhibitors now serve as unique tools which are perfectly designed to elucidate the molecular anatomy of the pathways that guide immune responses.
System notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Processing Action digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Notes Description based on print version record.
Other author Koszinowski, U. H. (Ulrich H.)
Hengel, H. (Hartmut)
Subject Viral proteins.
Major histocompatibility complex.
Immune response.
Immune response.
Major histocompatibility complex.
Viral proteins.
Electronic books.
ISBN 9783642594212 (electronic bk.)
3642594212 (electronic bk.)
9783540432616 (alk. paper)
3540432612 (alk. paper)