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Title Biliary disease : from science to clinic / Gideon Hirschfield, David Adams, Evaggelia Liaskou, editors.

Published Cham, Switzerland : Springer, [2017]


Location Call No. Status
Physical description 1 online resource : color illustrations
Series Springer Medicine eBooks 2017 English+International
Bibliography Includes bibliographical references.
Contents Preface; Contents; 1: The Clinical Burden of€Biliary Disease: A€Global Perspective; 1.1 Pediatric Cholestatic Disorders; 1.2 Extrahepatic Biliary Atresia; 1.3 Progressive Familial Intrahepatic Cholestatic Syndromes; 1.4 Drug-Induced Cholestasis; 1.5 Primary Biliary Cholangitis; 1.6 Primary Sclerosing Cholangitis; 1.7 Autoimmune Sclerosing Cholangitis/IgG4 Cholangiopathy; 1.8 Cholangiocarcinoma; 1.9 Gallbladder Cancer; 1.10 Gallstone Disease; References; 2: The Healthy Biliary Tree: Cellular and€Immune Biology; 2.1 The Normal Biliary Tree; 2.2 Development of€the€Bile Duct Epithelium.
2.2.1 Morphogens and€Transcription Factors Involved in€Biliary Lineage Specification and€Bile Duct Formation2.3 Biological Properties Enabling Cholangiocytes to€Respond to€Liver Damage; 2.3.1 Reactive Ductular Cells: The€Main Element of€the€Hepatic Response to€Damage; 2.3.2 Cholangiocyte Proliferation; 2.3.3 Cholangiocyte Role in€Bile Secretion; 2.3.4 Cholangiocytes in€Inflammation; 2.3.5 Cholangiocytes and€Innate Immunity; TLR Signaling; Cholangiocyte Secretion of€IgA and€Antimicrobial Peptides; 2.3.6 Cholangiocyte Involvement in€Antigen Presentation; References.
3: Pathological Features of€Biliary Disease in€Children and€Adults3.1 What Are the€Pathological Features of€Biliary Disease?; 3.1.1 Bile Duct Lesions; 3.1.2 Ductular Reaction; 3.1.3 Cholestasis; Bilirubinostasis; Cholate Stasis; 3.1.4 Inflammation; 3.1.5 Fibrosis; 3.1.6 Assessment of€Disease Severity in€Chronic Biliary Disease: Grading and€Staging; 3.2 Histological Changes in€Specific Diseases; 3.2.1 Developmental/Genetic Diseases; Biliary Atresia; Syndromic and€Non-syndromic Paucity of€Intrahepatic Bile Ducts.
Syndromic Paucity of€Intrahepatic Bile Ducts (Alagille Syndrome)Non-syndromic Paucity of€Intrahepatic Bile Ducts; Diseases Associated with€Ductal Plate Malformation; Cystic Fibrosis; Progressive Familial Intrahepatic Cholestasis (PFIC); 3.2.2 Immune-Mediated Biliary Diseases; Primary Biliary Cholangitis (PBC); Primary Sclerosing Cholangitis (PSC); Autoimmune Sclerosing Cholangitis (ASC); IgG4-Associated Sclerosing Cholangitis; Sarcoidosis; Transplant-Related Bile Duct Diseases.
3.2.3 Vascular Diseases Associated with€Bile Duct Injury3.2.3.1 Hepatic Arterial Occlusion ("Ischaemic Cholangiopathy"); "Sclerosing Cholangitis in€Critically Ill Patients" (SC-CIP); Portal Vein Occlusion ("Portal Hypertensive Biliopathy"); 3.2.4 Infective Causes of€Biliary Disease; 3.2.5 Drugs and€Iatrogenic Causes of€Biliary Disease; Drug-Induced Cholestasis; Intestinal Failure-Associated Liver Disease (IFALD); 3.2.6 Neoplastic Diseases Associated with€Cholestasis or Bile Duct Injury; Langerhans Cell Histiocytosis.
Summary This book addresses the current understanding of the diagnosis and management of biliary disease across all ages, with emphasis on how the latest advances in clinical science may be integrated into current and future therapies. The coverage is wide ranging, encompassing congenital and acquired conditions including cholestatic syndromes, biliary atresia, drug-induced cholestasis, primary biliary cholangitis/cirrhosis, primary sclerosing cholangitis, cholangiocarcinoma, gallstone disease, and autoimmune sclerosing cholangitis. With contributions from basic and clinical scientists, the relevance of state-of-the-art mechanistic biology to diagnosis, treatment, and future opportunities for drug design is clearly explained. The balance between science and clinical practice will ensure that this book makes a lasting contribution to the field. A broad readership will find the book easy to access and a rich source of information on current best practice and evolving management strategies.
Other author Hirschfield, Gideon M., editor.
Adams, David, 1958- editor.
Liaskou, Evaggelia, editor.
SpringerLink issuing body.
Subject Biliary tract -- Diseases.
Electronic books.
Electronic book.
ISBN 9783319501680 (electronic bk.)
3319501682 (electronic bk.)
Standard Number 10.1007/978-3-319-50168-0