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Title COPD : heterogeneity and personalized treatment / Sang-Do Lee, editor.

Published Berlin, Germany : Springer, 2017.


Location Call No. Status
Physical description 1 online resource
polychrome rdacc
Series Springer Medicine eBooks 2017 English+International.
Bibliography Includes bibliographical references and index.
Contents ""Preface""; ""Contents""; ""Part I: Overview""; ""1: Definition and Epidemiology of COPD""; "" Definition of COPD""; "" Epidemiology of COPD""; "" Prevalence""; "" Incidence""; "" Mortality""; "" Economic and Social Burden""; ""References""; ""2: Risk Factors: Factors That Influence Disease Development and Progression""; "" Genes""; "" Gender""; "" Lung Growth and Development""; "" Exposure to Particles""; "" Cigarette Smoking""; "" Occupational Exposures to Dusts, Chemical Agents, Fumes""; "" Indoor Air Pollution""; "" Outdoor Air Pollution""; "" Socioeconomic Status""
"" Asthma/Bronchial Hyperactivity"""" Infections""; ""References""; ""3: Pathology of Chronic Obstructive Pulmonary Diseases""; "" Introduction""; "" Lung Volumes in Lung Stereology""; "" Normal Lung""; "" Overall Structure""; "" Alveolar Tissue""; "" Small Airways""; "" Lung Cellular Composition""; "" Lung Growth""; "" Aged Lung""; "" COPD""; "" Chronic Bronchitis""; "" Small Airways""; "" Emphysema""; "" Quantification of Emphysema""; "" Microscopic Assessments of Emphysema""; "" Other Forms of Emphysema""; "" Involvement of Cellular Compartments in Emphysema""
"" Physiologicalâ#x80;#x93;Pathological Correlations"""" Pulmonary Vascular Structure and Function""; ""References""; ""4: Pathogenesis of COPD""; "" COPD Is an Inflammatory Disease""; "" Inflammatory Cells in COPD""; "" Airway Epithelial Cells""; "" Alveolar Macrophages""; "" Neutrophils""; "" Dendritic Cells""; "" Lymphocytes""; "" Other Cells""; "" Inflammatory Mediators in COPD""; "" Pathogenesis of Emphysema""; "" Protease-Antiprotease Imbalance in the Pathogenesis of COPD""; "" Protease-Antiprotease Imbalance in α1-Antitrypsin Deficiency""
"" Protease-Antiprotease Imbalance in COPD Without Antitrypsin Deficiency"""" Oxidative Stress in the Pathogenesis of COPD""; "" Physiological Roles of Radical Species""; "" Oxidative Stress in the Pathogenesis of COPD""; "" Cell Death and Impaired Repair in COPD""; "" Other Pathogenetic Mechanism of Emphysema""; "" Accelerated Aging""; "" Autoimmunity and COPD""; "" Epigenetic Changes in COPD Development""; "" Pathogenesis of Airway Obstruction""; "" Infiltration of Inflammatory Cells in Small Airways""; "" Mucus Hypersecretion""; "" Airway Remodeling""
"" Unanswered Question""""References""; ""Part II: Assessment""; ""5: Pathophysiology of COPD""; "" Mucus Hypersecretion and Ciliary Dysfunction""; "" Airflow Obstruction""; "" Hyperinflation""; "" Abnormality of Gas Exchange""; "" Pulmonary Arterial Hypertension""; "" Pathophysiology of COPD Exacerbation""; ""References""; ""6: Diagnosis and Assessment of COPD""; "" Introduction""; "" Diagnosis""; "" Symptoms""; "" Medical History""; "" Physical Examination""; "" Introduction to Pulmonary Function Testing""; "" Spirometry""; "" Lung Volumes""
Summary This book explains how analysis of the heterogeneity of chronic obstructive pulmonary disease (COPD) enhances understanding of the condition and leads to improved, personalized treatment. State of the art knowledge is presented on a range of issues related to the heterogeneity of COPD, such as phenotypes (clinical, physiologic, radiologic, etc.), genotypes, and the tools to be used for dissecting heterogeneity (CT, MRI, biomarkers, etc.). Especially modern radiologic imaging holds promise in this context, and its role is described in detail with the aid of numerous illustrations. The implications of the heterogeneity for personalized treatment are clearly identified, with description of an appropriate tailored treatment strategy for each subgroup of patients. Information is provided on both current and emerging strategies, including bronchoscopic lung volume reduction and approaches to the management of pulmonary hypertension and comorbidities. This book will be a great asset in clinical practice and research for all who have an interest in COPD, a leading cause of morbidity and mortality worldwide.
Other author Lee, Sang-Do, editor.
SpringerLink (Online service), issuing body.
Subject Lungs -- Diseases, Obstructive.
Internet Resources.
Standard Number 10.1007/978-3-662-47178-4
ISBN 9783662471784 (electronic bk.)
3662471787 (electronic bk.)
9783662471777 (print)