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LEADER 00000cam a22004934a 4500 
001    000044466363 
003    AuCNLKIN 
005    20090714165531.0 
008    090221t20092009nyua     b    001 0 eng d 
010    2009921196 
019 1  44466363 
020    9781603273169|q(hbk. : alk. paper) 
020    1603273166|q(hbk. : alk. paper) 
020    9781603273176|q(eISBN) 
020    1603273174|q(e-ISBN) 
035    .b32667048 
040    NLM|beng|cNLM|dBTCTA|dYDXCP|dSCB|dBWX|dCUS|dCDX|dVS:CL 
042    pcc 
050  4 QP552 
060 00 W1|bME9616J v.552 2009 
060 10 QU 25|bG1111 2009 
082 04 612/.01575|222 
245 00 G protein-coupled receptors in drug discovery /|cedited by
       Wayne R. Leifert. 
264  1 New York :|bHumana Press,|c[2009] 
264  4 |c©2009 
300    xi, 376 pages ;|cillustrations. 
336    text|btxt|2rdacontent 
337    unmediated|bn|2rdamedia 
338    volume|bnc|2rdacarrier 
490 1  Methods in molecular biology ;|v552. 
490 1  Springer protocols. 
504    Includes bibliographical references and index. 
505 0  New insights into GPCR function: implications for HTS / 
       R.M. Eglen and T. Reisine -- Screening technologies for G 
       protein-coupled receptors: from HTS to uHTS / M. De los 
       Frailes and E. Diez -- GPCR signaling: understanding the 
       pathway to successful drug discovery / C. Williams and 
       S.J. Hill -- An overview on GPCRs and drug discovery: 
       structure-based drug design and structural biology on 
       GPCRs / K. Lundstrom -- Understanding the ligand-receptor-
       G protein ternary complex for GPCR drug discovery / V.R. 
       Ratnala and B. Kobilka -- Assay data quality assessment / 
       H. Gubler -- Homology modeling of GPCRs / J. Simms ... [et
       al.] -- GPCR expression using baculovirus-infected Sf9 
       cells / A.L. Aloia ... [et al.] -- Radioligand binding 
       assays: application of [(125)I]angiotensin II receptor 
       binding / W.R. Leifert ... [et al.] -- [35S]GTPgammaS 
       binding in G protein-coupled receptor assays / T. Cooper, 
       E.J. McMurchie and W.R. Leifert -- A time-resolved 
       fluorescent lanthanide (Eu)-GTP binding assay for 
       chemokine receptors as targets in drug discovery / J. 
       Labrecque, R.S. Wong and S.P. Fricker -- Use of the 
       DiscoveRx Hit hunter cAMPII assay for direct measurement 
       of cAMP in Gs and Gi GPCRs / J. Bradley and D. McLoughlin 
       -- Use of aequorin for G protein-coupled receptor hit 
       identification and compound profiling / S.J. Brough and P.
       Shah -- BacMam: versatile gene delivery technology for 
       GPCR assays / E.A. Davenport, P. Nuthulaganti and R.S. 
       Ames -- Yeast assays for G protein-coupled receptors / 
       S.J. Dowell and A.J. Brown -- GPCR microspot assays on 
       solid substrates / Y. Fang and J. Lahiri -- Resonant 
       waveguide grating biosensor for whole-cell GPCR assays / 
       Y. Fang, A.M. Ferrie and E. Tran -- FRET-based measurement
       of GPCR conformational changes / S. Granier ... [et al.] -
       - FLIPR assays of intracellular calcium in GPCR drug 
       discovery / K.B. Hansen and H. Brauner-Osborne -- Use of 
       fluorescence indicators in receptor ligands / K.G. 
       Harikumar and L.J. Miller -- Application of fluorescence 
       resonance energy transfer techniques to establish ligand-
       receptor orientation / K.G. Harikumar and L.J. Miller -- 
       Detection of GPCR/beta-arrestin interactions in live cells
       using bioluminescence resonance energy transfer technology
       / M. Kocan and K.D. Pfleger -- Using reporter gene 
       technologies to detect changes in cAMP as a result of GPCR
       activation / D.J. Rodrigues and D. McLoughlin -- A quantum
       dot-labeled ligand-receptor binding assay for G protein-
       coupled receptors contained in minimally purified membrane
       nanopatches / J.L. Swift, M.C. Burger and D.T. Cramb -- 
       Xenopus oocyte electrophysiology in GPCR drug discovery / 
       K.B. Hansen and H. Brauner-Osborne -- Immunoprecipitation 
       and phosphorylation of G protein-coupled receptors / W.G. 
       Thomas. 
650  0 G proteins|0http://id.loc.gov/authorities/subjects/
       sh89000191|xReceptors.|0http://id.loc.gov/authorities/
       subjects/sh2002007652 
650  0 Drug development.|0http://id.loc.gov/authorities/subjects/
       sh97007921 
700 1  Leifert, Wayne Richard,|d1969- 
830  0 Methods in molecular biology (Clifton, N.J.) ;|0http://
       id.loc.gov/authorities/names/n92002874|vv. 552. 
830  0 Springer protocols (Series)|0http://id.loc.gov/authorities
       /names/no2008180772 
907    .b32667048 
984    VU|b.b32667048|cheld 
990    MARCIVE MELB 201906 
990    Uploaded to LA VU-B.D175 30/10/09 aci 
Location Call No. Status
 UniM BioMed ST  574.88078 METH  v.552    AVAILABLE