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Title G protein-coupled receptors in drug discovery [electronic resource] / edited by Wayne R. Leifert.

Published New York : Humana Press, c2009.


Location Call No. Status
Physical description 1 online resource (xi, 376 p.) : ill.
Series Springer protocols
Methods in molecular biology, ; 552
Methods in molecular biology (Clifton, N.J.) ; v. 552.
Springer protocols.
Bibliography Includes bibliographical references and index.
Contents New insights into GPCR function: implications for HTS / R.M. Eglen and T. Reisine -- Screening technologies for G protein-coupled receptors: from HTS to uHTS / M. De los Frailes and E. Diez -- GPCR signaling: understanding the pathway to successful drug discovery / C. Williams and S.J. Hill -- An overview on GPCRs and drug discovery: structure-based drug design and structural biology on GPCRs / K. Lundstrom -- Understanding the ligand-receptor-G protein ternary complex for GPCR drug discovery / V.R. Ratnala and B. Kobilka -- Assay data quality assessment / H. Gubler -- Homology modeling of GPCRs / J. Simms ... [et al.] -- GPCR expression using baculovirus-infected Sf9 cells / A.L. Aloia ... [et al.] -- Radioligand binding assays: application of [(125)I]angiotensin II receptor binding / W.R. Leifert ... [et al.] -- [35S]GTPgammaS binding in G protein-coupled receptor assays / T. Cooper, E.J. McMurchie and W.R. Leifert -- A time-resolved fluorescent lanthanide (Eu)-GTP binding assay for chemokine receptors as targets in drug discovery / J. Labrecque, R.S. Wong and S.P. Fricker -- Use of the DiscoveRx Hit hunter cAMPII assay for direct measurement of cAMP in Gs and Gi GPCRs / J. Bradley and D. McLoughlin -- Use of aequorin for G protein-coupled receptor hit identification and compound profiling / S.J. Brough and P. Shah -- BacMam: versatile gene delivery technology for GPCR assays / E.A. Davenport, P. Nuthulaganti and R.S. Ames -- Yeast assays for G protein-coupled receptors / S.J. Dowell and A.J. Brown -- GPCR microspot assays on solid substrates / Y. Fang and J. Lahiri -- Resonant waveguide grating biosensor for whole-cell GPCR assays / Y. Fang, A.M. Ferrie and E. Tran -- FRET-based measurement of GPCR conformational changes / S. Granier ... [et al.] -- FLIPR assays of intracellular calcium in GPCR drug discovery / K.B. Hansen and H. Brauner-Osborne -- Use of fluorescence indicators in receptor ligands / K.G. Harikumar and L.J. Miller -- Application of fluorescence resonance energy transfer techniques to establish ligand-receptor orientation / K.G. Harikumar and L.J. Miller -- Detection of GPCR/beta-arrestin interactions in live cells using bioluminescence resonance energy transfer technology / M. Kocan and K.D. Pfleger -- Using reporter gene technologies to detect changes in cAMP as a result of GPCR activation / D.J. Rodrigues and D. McLoughlin -- A quantum dot-labeled ligand-receptor binding assay for G protein-coupled receptors contained in minimally purified membrane nanopatches / J.L. Swift, M.C. Burger and D.T. Cramb -- Xenopus oocyte electrophysiology in GPCR drug discovery / K.B. Hansen and H. Brauner-Osborne -- Immunoprecipitation and phosphorylation of G protein-coupled receptors / W.G. Thomas.
Notes Description based on print version record.
Other author Leifert, Wayne R.
Subject G proteins -- Receptors.
Drug development.
Protéines G -- Récepteurs.
Pharmacie -- Recherche.
ISBN 9781603273176 (Springer e-ISBN)
1603273174 (Springer e-ISBN)
9781603273169 (hbk. : alk. paper)
1603273166 (hbk. : alk. paper)