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PRINTED BOOKS
Author Van Regenmortel, M. H. V.

Title Synthetic peptides as antigens / M.H.V. Van Regenmortel, S. Müller.

Published Amsterdam ; New York : Elsevier, 1999.

Copies

Location Call No. Status
 UniM BioMed  616.0792 VAN    AVAILABLE
 UniM BioMed ST  616.0792 VAN    AVAILABLE
Physical description xvii, 381 pages : illustrations ; 21 cm.
Series Laboratory techniques in biochemistry and molecular biology ; 28.
Laboratory techniques in biochemistry and molecular biology ; 28.
Bibliography Includes bibliographical references (pages 319-374) and index.
Contents Chapter 1. Molecular dissection of protein antigens and the prediction of epitopes / M. H. V. Van Regenmortel 1 -- 1.2. Definition of antigenicity and the concept of epitope 3 -- 1.3. Types of epitopes 10 -- 1.4. Methods used for localizing epitopes 17 -- 1.5. Antigenic structure of model proteins 39 -- 1.6. Antigenicity prediction 53 -- 1.7. T-cell epitopes 68 -- Chapter 2. Peptide-carrier conjugation / S. Muller 79 -- 2.2. Choice of carrier 80 -- 2.3. Optimal peptide density on carrier protein 83 -- 2.4. Point of attachment on peptide chain 85 -- 2.5. Chemical coupling 85 -- 2.6. Photochemical coupling 109 -- 2.7. Coupling of peptides to liposomes 114 -- 2.8. Coupling of peptides to solid supports 119 -- 2.9. Determination of peptide: carrier ratio of conjugates 126 -- 2.10. Peptide derivatization 129 -- Chapter 3. Immunization with peptides / S. Muller 133 -- 3.2. Choice of animal 134 -- 3.3. Immunogen 136 -- 3.4. Adjuvant 158 -- 3.5. Route of injection 167 -- 3.6. Specific immunization protocols 169 -- Chapter 4. Peptide immunoassays / M. H. V. Van Regenmortel 179 -- 4.2. Types of solid-phase immunoassays 181 -- 4.3. Solid-phase immunoassay procedures 196 -- 4.4. Dot immunobinding assay 202 -- 4.5. Spotscan assay 203 -- 4.6. Biosensor assays 204 -- 4.7. Measurement of affinity constants 210 -- 4.8. Monitoring of the immune response to peptides 212 -- Chapter 5. Use of antipeptide antibodies in molecular and cellular biology / S. Muller 215 -- 5.1. Detection of gene products with antipeptide antibodies 215 -- 5.2. Use of antipeptide antibodies in immunohistochemistry and immunocytochemistry 232 -- Chapter 6. Use of peptides for diagnosing viral infections / M. H. V. Van Regenmortel 237 -- 6.1. Mimicry of viral epitopes with synthetic peptides 237 -- 6.2. Synthetic peptides for viral diagnosis 242 -- 6.3. Peptide-based immunoassays 244 -- Chapter 7. Peptides in diagnosis of autoimmune diseases / S. Muller 247 -- 7.2. Methods of detection and quantification of autoantibodies with synthetic peptides 248 -- 7.3. Specific examples of autoepitope mapping data 262 -- 7.4. Prediction of epitopes recognized by autoantibodies 273 -- 7.5. Peptides mimicking sites of post-translational modification recognized by autoantibodies 278 -- Chapter 8. Synthetic peptides as vaccines / M. H. V. Van Regenmortel 281 -- 8.2. Antiviral vaccines 284 -- 8.3. Vaccines against bacterial infections 310 -- 8.4. Vaccines against parasites 311 -- 8.5. Are molecular design strategies applicable to the development of synthetic vaccines? 313 -- 8.6. Empirical discovery rather than molecular design will bring about new synthetic vaccines 314.
Other author Muller, S.
Subject Proteins -- Immunology.
Synthetic antigens.
Antigenic determinants.
ISBN 0720442001 (series)
0444821759
0444821767 (paperback)