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Title Bacteriophage applications : historical perspective and future potential / Jessica Nicastro, Shirley Wong, Zahra Khazaei, Peggy Lam, Jonathan Blay, Roderick A. Slavcev.

Published Cham, Switzerland : Springer, 2016.


Location Call No. Status
Physical description 1 online resource (vii, 82 pages).
Series SpringerBriefs in biochemistry and molecular biology, 2211-9353
SpringerBriefs in biochemistry and molecular biology, 2211-9353
Springer English/International eBooks 2016 - Full Set
Bibliography Includes bibliographical references.
Contents 1 Overview of Bacteriophage Lifecycles and Applications; 1 Introduction; 2 Phage Infection and Life-Cycle; 2.1 Lytic Phage; 2.2 Temperate Phage; 3 Phage Infection Stages; 3.1 Phage Entry; 3.2 DNA Replication; 3.3 Phage Assembly; 3.3.1 Tailed (dsDNA) Phages; 3.3.2 ssDNA Phages; 3.3.3 ssRNA Phages; 4 Hurdles for Phage-Based Therapeutics; References; 2 Phage for Biocontrol; Abstract; 1 Introduction; 2 The Importance of Using Recombinant Phage; 3 Recombinant Phage for the Treatment of Bacterial Infections; 3.1 Escherichia coli (E. coli); 3.2 Staphylococcus aureus (S. aureus)
3.3 Chlamydia trachomatis3.4 Pseudomonas aeruginosa (PA); 3.5 Helicobacter pylori (H. pylori); 4 Phage as Drug Delivery Vehicles for the Treatment of Bacterial Infections; 5 Summary; References; 3 Phage Device Coatings; Abstract; 1 Introduction; 2 Biofilms on Medical Devices; 2.1 Contributors to Biofilm Resistance; 3 Alternative Medical Coating Devices; 4 Bacteriophage as Bioactive Coatings; 5 Conclusions; References; 4 Bacteriophages Functionalized for Gene Delivery and the Targeting of Gene Networks; Abstract; 1 Introduction to Phage Mediated Delivery of Genetic Material
2 Bacteriophages as Gene Delivery Vehicles3 Phages as Cytotoxic Agents in Eukaryotes; 4 Phages for Delivery to the Central Nervous System; 5 Conclusions; References; 5 Phage Probiotics; Abstract; 1 Introduction: The Gut Microbiota and Probiotics; 2 Roles of the Gut Microbiota and Probiotics; 2.1 Protection Against Pathogens; 2.2 Metabolism; 2.3 Immunomodulation; 2.4 Tissue Development and Maintenance; 3 Bacteriophages in the Gut; 3.1 Phage Population Dynamics; 3.2 Protection Against Pathogens and Immunomodulation; 4 Applications of Phage; 4.1 Lytic Phage Therapy; 4.2 Phage Biotechnology
5 ConclusionsReferences; 6 Phage for Biodetection; Abstract; 1 Introduction to Phage-Based Biodetection; 2 Plaque Assays; 2.1 Phage Display for the Improvement of Plaque Assays; 3 Bacteriophage Indicator Organisms (Reporter Phage); 3.1 Fluorescence-Based Assays; 4 Immobilized Phage Particles as Probes for Bacterial Detection; 5 Conclusions; References; 7 Phage-Mediated Immunomodulation; 1 Introduction; 2 Immune Responses to Phage; 2.1 Anti-phage Innate Responses; 2.2 Humoral Immune Reposes to Phage (Anti-phage Antibodies)
2.3 Anti-phage Cellular Immunity and the Implications of the Impact of Phage on the Adaptive Responses (T and B Cells)3 Bacteriophage-Based Immune-Pharmaco-Therapies; 3.1 Phage Immunogenicity and Cancer Therapy; 3.1.1 Phage in Tumor Targeting; 3.1.2 Anti-tumor Phage Therapies; 3.2 Bacteriophage Immunotherapy Autoimmune Disorders; 3.3 Bacteriophage Immunotherapy for Drug Addiction; 3.4 Phages and Oxidative Stress; 4 Conclusions; References
Summary This book explores key applications of phage biotechnology and reviews recent advances in phage display technologies. The applications covered were selected on the basis of their significance and representativeness in the field. The small size and enormous diversity of bacteriophages make them ideal candidates for numerous applications across many industries. Since the discovery of phages and the advent of phage display systems, considerable attention has been focused on the development of novel therapeutic and industrial applications. Recent studies combine the genomic flexibility of phages with phage display systems in order to generate modified phages for targeted delivery.
Other author Nicastro, Jessica, author.
Wong, Shirley, author.
Khazaei, Zahra, author.
Lam, Peggy, author.
Blay, Jonathan, author.
Slavcev, Roderick A. author.
SpringerLink issuing body.
Subject Bacteriophages.
Electronic books.
ISBN 9783319457918 (electronic bk.)
3319457918 (electronic bk.)
9783319457895 (print)
Standard Number 10.1007/978-3-319-45791-8