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Title Pathology and biology of human germ cell tumors / Francisco F. Nogales, Rafael E. Jimenez, editors.

Published Berlin : Springer, [2017]


Location Call No. Status
Physical description 1 online resource : illustrations
polychrome rdacc
Series Springer Medicine eBooks 2017 English+International.
Bibliography Includes bibliographical references and index.
Contents Preface; References; Contents; Contributors; 1: Germ Cell Tumors: Classifications, Definitions, and Terminology; 1.1 Introduction; 1.2 Classification of Testicular Germ Cell Tumors; 1.3 Classification of Ovarian Germ Cell Tumors; 1.4 Definitions and Terminology of Testicular and Ovarian Germ Cell Tumors; References; 2: The Epidemiology of Malignant Germ Cell Tumors: The EUROCARE Study; 2.1 Introduction; 2.2 Materials; 2.3 Incidence; 2.4 Incidence Trends of Gonadal and Extragonadal Germ Cell Tumors; 2.5 Survival; References.
3: Germ Cell Tumors from a Developmental Perspective: Cells of Origin, Pathogenesis, and Molecular Biology (Emerging Patterns); 3.1 Introduction; 3.2 Developmental States of Early Embryonic Cells; 3.2.1 Restriction Versus Maintaining Developmental Potential; 3.2.2 OCT4: Key Protein in Pluripotency; 3.2.3 Specification and Maintenance of the Germline; 3.2.4 Plasticity of Pluripotent States; 3.3 Developmental Potential of Germ Cell Tumors; 3.4 Type 0 GCT; 3.4.1 Developmental Potential and Incidence; 3.4.2 Anatomical Distribution; 3.4.3 Genetics and Pathogenesis; 3.5 Type I GCT.
3.5.1 Type I GCT General; Developmental Potential; Epidemiology; Anatomical Distribution; (Cyto)Genetics; Epigenetics, including GI; Animal Models and Pathogenesis; Summary of the Pathogenesis of Type I GCT; 3.5.2 Site-Specific Aspects of Type I GCT; Sacral Region; Retroperitoneum; Stomach; Mediastinum; Heart; Head and Neck; Brain; Testis; Ovary; 3.5.3 Type I GCT Beyond Infancy; 3.6 Type II GCT; 3.6.1 Type II GCT General. Developmental Potential; Epidemiology; Anatomical Distribution; (Cyto)Genetics; Epigenetics: Including GI and miRNAs; Sensitivity/Resistance/Residual Teratoma/Further Progression; Animal Models and Cell Lines; 3.6.2 Specific Aspects of Pathogenesis per Anatomical Site; Dysgenetic Gonad; Testis; Ovary; Mediastinum; Central Nervous System; 3.6.3 Type II GCT Before Puberty; 3.7 Type III GCT; 3.7.1 Developmental Potential; 3.7.2 Epidemiology/Risk Factors; 3.7.3 Anatomical Distribution.
3.7.4 (Cyto)Genetics; 3.7.5 Epigenetics Including GI; 3.7.6 Pathogenesis and Animal Models; 3.8 Type IV GCT; 3.8.1 Developmental Potential; 3.8.2 Epidemiology/Risk Factors; 3.8.3 Anatomical Distribution; 3.8.4 (Cyto)Genetics; 3.8.5 Epigenetics Including GI; 3.8.6 Pathogenesis and Animal Models; 3.9 Type V GCT; 3.9.1 Developmental Potential; 3.9.2 Epidemiology/Risk Factors; 3.9.3 Anatomical Distribution; 3.9.4 (Cyto)Genetics/Epigenetics Including GI; 3.9.5 Pathogenesis and Animal Models; 3.10 Type VI GCT; 3.10.1 Definition.
Summary This book provides, for the first time, a detailed, up-to-date, holistic approach to the pathology and biology of germ cell tumors. The main focus is the complex histopathology of these tumors, but special considerations are also given to their morphologic variations in relation to age, gender and organ. Critical updates are provided on terminology and classification; the discussion of biology and pathogenesis includes references to many molecular genetic and immunohistochemical findings from recent stem cell research. Individual chapters are devoted to germ cell tumors at different anatomic locations, including not only the ovaries and testes but also the mediastinum and central nervous system, and pediatric tumors. All of the contributing authors are opinion leaders from universities of excellence in Europe and the United States. This monograph will be of wide interest to practitioners and researchers in many fields of medicine, including pathology, gynecology, urology, and pediatrics, as well as stem cell scientists.
Other author Nogales Ortiz, Francisco, editor.
Jimenez, Rafael E., editor.
SpringerLink (Online service), issuing body.
Subject Germ cells -- Tumors.
Electronic books.
Electronic book.
Standard Number 10.1007/978-3-662-53775-6
ISBN 9783662537756 (electronic bk.)
3662537753 (electronic bk.)