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Title The behavioral neuroscience of drug discrimination / Joseph H. Porter, Adam J. Prus, editors.

Published Cham : Springer, 2018.


Location Call No. Status
Physical description 1 online resource.
Series Current topics in behavioral neurosciences ; 39
Current topics in behavioral neurosciences ; 39.
Springer Biomedical and Life Sciences eBooks 2018 English+International
Contents Intro; Preface; References; Contents; Drug Discrimination: Historical Origins, Important Concepts, and Principles; 1 Introduction; 2 Historical Origins; 2.1 State Dependent Learning; 2.2 Drug Discrimination; 2.3 Two-Lever Operant Drug Discrimination; 3 Important Concepts and Principles of the Drug Discrimination Paradigm; 3.1 A Method to Measure Subjective Effects; 3.2 Classification of Drugs; 3.3 Tolerance and Cross-Tolerance; 3.4 Stereospecificity of Discriminative Stimulus Effects; 3.5 Receptor Mechanisms and Discriminative Stimulus Effects; 3.6 Individual Differences Between Subjects.
3 Characterization of the Stimulus Effects of ( -- )-Nicotine4 Nicotine Stereoisomers; 4.1 Lethality; 4.2 Pharmacology; 5 Tobacco Alkaloids and Nicotine Metabolism; 6 Mechanism of Action; 6.1 Mecamylamine; 6.2 DHβE (Dihydro-β-Erythroidine); 6.3 Methyllycaconitine (MLA); 6.3.1 Summary and Analysis of Antagonism Results; 7 Pharmacotherapies for Smoking Cessation; 7.1 ( -- )Lobeline; 7.2 Bupropion; 7.3 Varenicline; 8 Summary and Conclusions; References; Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol; 1 Introduction; 1.1 Rodents; 1.1.1 GABA; 1.1.2 Glutamate.
3.7 Drug Development4 Summary and Overview of This Volume; References; Discriminative Stimulus Effects of Psychostimulants; 1 Introduction; 2 Discriminative Stimulus Effects of Psychostimulant Drugs; 3 A Note on the Sex of Experimental Subjects; 4 Monoamine Transporter Blocker: Cocaine; 4.1 Dopamine; 4.2 Norepinephrine; 4.3 Serotonin; 4.4 Non-monoaminergic Receptors; 5 Monoamine Transporter Substrate/Releaser: MDMA; 5.1 Stimulant: Hallucinogen Continuum; 5.2 Stereoisomerism; 5.3 Pharmacokinetic Considerations; 5.4 Discriminative Stimulus Effects of MDMA.
6 Monoamine Transporter Substrate/Releaser: d-Amphetamine and Methamphetamine6.1 d-Amphetamine: Prototypical DA Releaser; 6.2 Methamphetamine: Prototypical DA Releaser; 7 Conclusion; References; Discriminative Stimulus Properties of S( -- )-Nicotine: ̀̀A Drug for All Seasons;́́ 1 Introduction; 2 Drug Discrimination; 2.1 Why Use Drug Discrimination (DD) Procedures to Study S( -- )-Nicotine?; 2.2 Rationale; 2.3 Methodology; 2.3.1 Initial Shaping of Behavior; 2.3.2 Training Under Both Drug and Non-drug Conditions; 2.3.3 Testing Procedures; 2.3.4 Challenge Experiments; 2.3.5 Stimulus Generalization.
1.1.3 Serotonin1.2 Nonhuman Primates; 1.3 Humans; 1.4 Neuroanatomical Targets; 1.5 New Paradigm for Advancing Knowledge and Pharmacotherapeutic Development with Ethanol Discriminations; References; Discriminative Stimulus Effects of Abused Inhalants; 1 Introduction; 2 Unique Methodological Aspects of Inhalant Discrimination Studies; 3 Inhalants as Drug Discrimination Training Stimuli; 4 Pharmacological Characterization of Inhalant Discriminative Stimuli; 4.1 Stimulus Effects of Inhalants: GABAA Receptors; 4.2 Stimulus Effects of Inhalants: NMDA Receptors.
Summary The goal for this volume is to provide an up-to-date review of the discriminative stimulus properties of major psychoactive drug classes with an emphasis on how this paradigm enhances our understanding of these drugs and how these findings translate from animals to humans. The drug discrimination paradigm applies to both drugs of abuse and drugs for treating mental illnesses, and research from these studies has provided immense translational value for learning about the mechanisms responsible for drug effects in humans.
Other author Porter, Joseph H., 1949- editor.
Prus, Adam J., editor.
SpringerLink issuing body.
Subject Drug discrimination (Pharmacology)
Electronic books.
ISBN 9783319985619 (electronic bk.)
3319985612 (electronic bk.)
Standard Number 10.1007/978-3-319-98561-9