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Cover Art
Author Rumbaut, Rolando E.

Title Platelet-vessel wall interactions in hemostasis and thrombosis [electronic resource] / Rolando E. Rumbaut and Perumal Thiagarajan.

Published San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, c2010.


Location Call No. Status
Physical description 1 electronic text (viii, 67 p. : ill.) : digital file.
Series Synthesis lectures on integrated systems physiology, from molecules to function, 1947-9468 ; # 4
Colloquium digital library of life sciences.
Colloquium series on integrated systems physiology, from molecule to function, 1947-9468 ; # 4.
Notes Part of: Colloquium digital library of life sciences.
Title from PDF t.p. (viewed on March 17, 2010).
Series from website.
Bibliography Includes bibliographical references (p. 45-67).
Contents 1. Introduction -- 2. General characteristics of platelets -- Overview -- Platelet granules -- Alpha granules -- Dense granules -- Lysosomes -- Platelet adhesion molecules -- P-selectin -- Glycoprotein Ib/IX/V (GPIb/IX/V) -- Glycoprotein IIb/IIIa (GP IIb/IIIa) -- Collagen receptors -- G-protein-coupled receptors -- Thrombin -- Adenosine diphosphate (ADP) and adenosine triphosphate (ATP) -- Prostanoids --
3. Platelet adhesion to vascular walls -- Adhesion to subendothelium following vascular injury -- Von Willebrand factor (vWF) -- Collagen -- Other subendothelial components -- Endogenous mechanisms preventing platelet adhesion to endothelium -- Nitric oxide -- Prostacyclin -- Ecto-adenosine diphosphatase (ADPase) -- Endothelial surface layer -- Mechanisms of platelet adhesion to endothelium -- Endothelial P-selectin-dependent mechanisms -- Endothelial vWF-dependent mechanisms -- Other mechanisms --
4. Platelet aggregation -- Mechanisms of platelet aggregation -- Monitoring of platelet aggregation -- Ex vivo monitoring: platelet aggregometry -- In vivo monitoring of platelet aggregation --
5. Platelet recruitment and blood coagulation -- Role of platelets -- Role of platelet-leukocyte interactions --
6. Arterial, venous, and microvascular hemostasis/thrombosis -- Venous thrombosis -- Endothelial injury -- Hypercoagulability -- Stasis -- Coexistence of Virchow's triad components: cancer and thrombosis -- Arterial thrombosis -- Microvascular thrombosis --
7. Summary -- Bibliography.
Restrictions Abstract freely available; full-text restricted to subscribers or individual document purchasers.
Summary Platelets are essential mediators of the physiologic process of hemostasis and pathologic thrombosis. While platelets do not interact with vascular walls under normal conditions, vascular injury or inflammation result in a coordinated series of events including platelet adhesion, aggregation, and promotion of coagulation. In this review, we describe the primary mechanisms involved in these responses in various vascular beds of both macro- and microvessels, and outline key unresolved aspects of these important interactions.
Other formats Also available in print.
System notes Mode of access: World Wide Web.
System requirements: Adobe Acrobat reader.
Other author Thiagarajan, Perumal.
Subject Thrombosis.
Blood platelets.
ISBN 9781615040407 (electronic bk.)
9781615040391 (pbk.)
Standard Number 10.4199/C00007ED1V01Y201002ISP004