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Title Anticoagulation therapy / Joe F. Lau, Geoffrey D. Barnes, Michael B. Streiff editors.

Published Cham, Switzerland : Springer, [2018]


Location Call No. Status
Physical description 1 online resource
Series Springer Medicine eBooks 2018 English+International
Bibliography Includes bibliographical references and index.
Contents Intro; Preface; Acknowledgments; Abbreviations; Contents; 1: Introduction; Anticoagulation Therapy: A Historical Perspective; The Evolving Anticoagulant Armamentarium; Resources for Anticoagulation Management; Exploring the Future of Anticoagulation Care; References; Part I: Anticoagulants; 2: Warfarin; Introduction; Pharmacology; Mechanism of Action; Pharmacokinetics; Absorption; Distribution; Metabolism; Elimination; Pharmacodynamics; Clinical Utility; Practical Management; Patient Engagement and Education; Dosing: Initiation; Dosing: Maintenance; Administration; Monitoring.
Transitioning Between Warfarin and Other AnticoagulantsManagement of Warfarin Around Elective Procedures; Adverse Effects; Skin Necrosis; Purple Toe Syndrome; Other Adverse Effects; Bleeding; Reversal; INR Derangements in Asymptomatic Patients; INR 9; Bleeding Events; Nonmajor Bleeding; Major Bleeding; Urgent or Emergent Procedures; Special Considerations; Pregnancy; Breastfeeding; Pediatric Patients; Conclusion; References; 3: Unfractionated Heparin and Low-ƯMolecular-ƯWeight Heparin; Introduction; Unfractionated Heparin; Pharmacokinetics and Pharmacodynamics.
Clinical Indications and DosingMonitoring; Considerations in Special Populations; Obesity; Pregnancy; Strategies for Reversal of Unfractionated Heparin; Complications; Heparin Resistance; Osteopenia; Heparin-Induced Thrombocytopenia; Low-Molecular-Weight Heparin; Pharmacodynamics; Pharmacokinetics; Clinical Indications and Dosing; Considerations in Special Populations; Obesity; Renal Dysfunction and Elderly Patients; Pregnancy; Strategies for Reversal of Low-ƯMolecular-ƯWeight Heparins; Summary; References; 4: Parenteral Anticoagulants: Direct Thrombin Inhibitors and Pentasaccharides.
Parenteral Direct Thrombin Inhibitors (Argatroban and Bivalirudin)Pharmacology; Mechanism of Action; Pharmacokinetics; Absorption; Distribution; Metabolism; Elimination; Pharmacodynamics; Clinical Utility; Heparin-Induced Thrombocytopenia (HIT); Argatroban; Bivalirudin; Coronary Reperfusion; Percutaneous Coronary Intervention (PCI) in Patients without HIT; Argatroban; Bivalirudin; Percutaneous Coronary Intervention (PCI) in Patients with HIT; Argatroban; Bivalirudin; Acute Myocardial Infarction (NSTEMI or STEMI) in Patients Who Cannot Undergo PCI; CABG with or Without HIT.
Practical ManagementDosing; Administration; Monitoring and Titration; HIT; Coronary Reperfusion; Argatroban; Bivalirudin; Transitioning to Oral Anticoagulation; HIT; Argatroban; Bivalirudin; Coronary Reperfusion; Other Clinical Uses; Continuous Renal Replacement Therapy; ECMO; Adverse Effects; Reversal; Special Considerations; Pregnancy; Breastfeeding; Pediatric; Fondaparinux; Pharmacology; Mechanism of Action; Pharmacokinetics; Absorption; Distribution; Metabolism; Elimination; Renal Function; Age; Low Body Weight; Pharmacodynamics; Clinical Utility; Prevention of VTE; Orthopedic Surgery.
Summary This book presents the latest evidence and guidelines supporting the use of anticoagulant therapy for various clinical scenarios. The field of anticoagulation therapy is evolving rapidly, particularly since the arrival and widespread adoption of direct oral anticoagulants. Organized in two parts, this book reviews the pharmacologic properties of various anticoagulants and details the clinical applications of anticoagulant therapy. Drugs such as warfarin and unfractionated heparin, as well as parenteral and direct oral anticoagulants are discussed in terms of their pharmacokinetics, drug-disease interactions, dosing strategies, and risk considerations. Clinical applications of anticoagulant therapy in disorders such as acute coronary syndromes, atrial fibrillation, and thrombophilia and in special populations such as pregnant women, the elderly, and in the patient with cancer are highlighted. Clinical vignettes, algorithms, clinical pearls, and self-assessment questions are integrated throughout the book. Featuring contributions from authorities in the field, Anticoagulation Therapy is an essential resource for cardiologists, vascular medicine specialists, hematologists, internists, and all other healthcare professionals who prescribe anticoagulants.
Other author Lau, Joe F., editor.
Barnes, Geoffrey D., editor.
Streiff, Michael B., editor.
SpringerLink issuing body.
Subject Anticoagulants (Medicine)
Anticoagulants (Medicine) -- Therapeutic use.
Electronic books.
ISBN 9783319737096 (electronic bk.)
3319737090 (electronic bk.)
Standard Number 10.1007/978-3-319-73709-6