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Author Tofilon, Philip J., speaker.

Title Global analysis of gene translation / Philip Tofilon.

Published London : Henry Stewart Talks, 2009.


Location Call No. Status
Physical description 1 streaming video file (38 minutes) : digital, mono, SWF file, sound, colour.
Series Microarrays : their design and use.
Henry Stewart talks. Biomedical & life sciences collection. Microarrays : their design and use.
Notes Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents Contents: Radiation-induced gene expression has long been considered to play a role in determining cellular radioresponse -- Analyses of single genes and whole genomes indicate that radiation-induced changes at the mRNA level do not correlate with changes in corresponding proteins -- Microarray analysis of polysome-bound RNA indicates that radiation modifies the translational activity of mRNA subpopulations, which correlates with protein products -- Gene translation is considerably more susceptible to radiation-induced changes than is the transcriptome -- Defining the genes whose translation is modified by radiation may provide an approach for identifying critical proteins and pathways that serve as determinants of radiosensitivity.
Restrictions Access restricted to subscribers.
System notes Mode of access: World Wide Web.
System requirements: Operating System: PC Windows 2000+, Mac OSX+ 3.2. Browser Compatibility: IE6+, Firefox 2+, Opera 9+, Safari 2+ 3.3. Browser settings: enable JavaScript, enable popups from the Henry Stewart Talks site. 3.4. Required Browser Plugins & Viewers: Adobe (Macromedia) Flash Player 7+, Adobe Acrobat Reader 6.0+.