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Title Dengue and Zika : control and antiviral treatment strategies / Rolf Hilgenfeld, Subhash G. Vasudevan, editors.

Published Singapore : Springer, [2018]


Location Call No. Status
Physical description 1 online resource (xiii, 375 pages) : illustrations (chiefly color).
Series Advances in experimental medicine and biology, 2214-8019 ; volume 1062
Advances in experimental medicine and biology ; v. 1062. 0065-2598
Springer Biomedical and Life Sciences eBooks 2018 English+International
Bibliography Includes bibliographical references and index.
Contents Arboviruses on the rise -- Historical perspective of arboviruses in Mozambique and its implication for current and future epidemics -- Reliable serological testing for the diagnosis of emerging infectious diseases -- Flaviviral RNA structures and their role in replication and immunity -- The molecular specificity of the human antibody response to dengue virus infections -- Structures of Zika virus E & NS1: relations with virus infection and host immune responses -- Plugging the leak -- is dengue a case of aseptic shock with NS1 at its center -- Entry & NS1 as drug targets -- The dengue virus replication complex: from RNA replication to protein-protein interactions to evasion of innate immunity -- Crystal structure of Zika virus NS2B-NS3 protease -- The transactions of NS3 and NS5 in Dengue viral RNA replication -- Establishment and application of flavivirus replicons -- Strategies towards protease inhibitors for emerging flaviviruses -- Discovery of potent non-nucleoside inhibitors of dengue viral RNA-dependent RNA polymerase from fragment screening and structure-guided design -- Nuclear cytoplasmic trafficking of dengue non-structural protein 5 as a target for antivirals -- Animal models for dengue and Zika vaccine development -- Understanding the human T cell response to dengue virus -- Regulation and function of NK and T cells during dengue virus infection and vaccination -- Structural insights into the broad-spectrum antiviral target Endoplasmic Reticulum alpha glucosidase II -- Mechanisms of antiviral activity of iminosugars against dengue virus -- Countering Zika virus: the USAMRIID response -- Dengue antiviral development: a continuing journey -- An industry perspective on dengue drug discovery and development -- The use of wolbachia by the Eliminate Dengue program to interrupt transmission of Aedes aegypti transmitted viruses -- Seroepidemiological studies of arboviruses in Africa.
Summary "This contributed volume contains 25 chapters from leading international scientists working on Dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. The meeting venue offered an opportunity to discuss current research on these flaviviruses in an idyllic setting, and also to develop first-hand appreciation of the issues in infectious diseases facing developing countries and of the research gaps in Africa. For readers, who should include basic and clinical researchers in the field and public health professionals, the chapters are organized to provide a comprehensive overview of the various topics in current dengue and Zika virus research. A unique feature of the proceedings of this meeting is the inclusion of the discussions that took place following presentations. These have been transcribed and appended to the end of the relevant chapters, and they form the "salt in the soup" of this book."-- Provided by publisher.
Other author Hilgenfeld, R. (Rolf), editor.
Vasudevan, Subhash, editor.
SpringerLink issuing body.
Tofo Advanced Study Week on Emerging Viral Diseases (2nd : 2016 : Praia do Tofo, Mozambique), author.
Subject Dengue -- Congresses.
Zika virus infection -- Congresses.
Electronic books.
Conference papers and proceedings.
ISBN 9789811087271 (electronic bk.)
981108727X (electronic bk.)
9789811087264 (hardcover ; alk. paper)
9811087261 (hardcover ; alk. paper)
Standard Number 10.1007/978-981-10-8727-1