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LEADER 00000cam a2200541Ii 4500 
003    OCoLC 
005    20160430091234.2 
006    m     o  d         
007    cr cnu|||unuuu 
008    150310t20152015sz a    o     001 0 eng d 
019    SPRINGERocn904597987 
020    9783319130811 
020    3319130811 
020    |z9783319130804 
020    3319130803|q(print) 
020    9783319130804|q(print) 
024 7  10.1007/978-3-319-13081-1 
040    N$T|beng|erda|epn|cN$T|dGW5XE|dN$T|dIDEBK|dCDX|dUPM|dCOO
       |dE7B|dEBLCP|dYDXCP|dVLB|dOCLCF 
049    MAIN 
050  4 RS201.A56|bA58 2015eb 
082 04 615.3/7|223 
245 00 Antibody-drug conjugates :|bthe 21st century magic bullets
       for cancer /|cJeffrey Wang, Wei-Chiang Shen, Jennica L. 
       Zaro, editors. 
264  1 Cham :|bSpringer,|c[2015] 
264  4 |c©2015 
300    1 online resource (x, 252 pages) :|billustrations (some 
       color). 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
490 1  AAPS advances in the pharmaceutical sciences series,|x2210
       -7371 ;|vvolume 17 
500    Includes index. 
504    Includes bibliographical references and index at the end 
       of each chapters. 
505 0  1 Antibody-Drug Conjugates: A Historical Review -- 2 
       Payloads of Antibody-Drug Conjugates -- 3 Selecting an 
       Optimal Antibody for Antibody-Drug Conjugate Therapy -- 4 
       Linker Design for Antibody-Drug Conjugates -- 5 
       Formulation Development for Antibody-Drug Conjugates -- 6 
       Bioanalytical Assay for Characterization of Antibody Drug 
       Conjugates -- 7 Pharmacokinetics/Pharmacodynamics and 
       Disposition of Antibody-Drug Conjugates -- 8 Regulatory 
       Considerations -- 9 Major ADC Companies, Current Clinical 
       Trials, Recent Patents Issued and Patent Applications, and
       Cost Analysis of Drug Therapy -- 10 Mylotarg: Revisiting 
       its Clinical Potential Post-Withdrawal -- 11 ADCETRIS: A 
       Regulatory Case Study of a New Generation Antibody Drug 
       Conjugate -- 12 Ado-Trastuzumab Emtansine -- 13 The 
       Antibody-Drug Conjugate Glembatumumab Vedotin (CDX-011) 
       and its Use in Treatment of Breast Cancer -- 14 Summary 
       and Future Directions. 
520    This authoritative volume provides a holistic picture of 
       antibody-drug conjugates (ADCs). Fourteen comprehensive 
       chapters are divided into six sections including an 
       introduction to ADCs, the ADC construct, development 
       issues, landscape, IP and pharmacoeconomics, case studies,
       and the future of the field. The book examines everything 
       from the selection of the antibody, the drug, and the 
       linker to a discussion of developmental issues such as 
       formulations, bio-analysis, pharmacokinetic-
       pharmacodynamic relationships, and toxicological and 
       regulatory challenges. It also explores pharmacoecomonics 
       and intellectual properties, including recently issued 
       patents and the cost analysis of drug therapy. Case 
       studies are presented for the three ADCs that have 
       received FDA approval: gemtuzumab ozogamicin (Mylotarg®), 
       Brentuximab vedotin (Adcetris®), and ado-trastuzumab 
       emtansine (Kadcyla®), as well as an ADC in late-stage 
       clinical trials, glembatumumab vedotin (CDX-011). Finally,
       the volume presents a perspective by the editors on the 
       future directions of ADC development and clinical 
       applications. Antibody-Drug Conjugates is a practical and 
       systematic resource for scientists, professors, and 
       students interested in expanding their knowledge of 
       cutting-edge research in this exciting field. 
650  0 Antibody-drug conjugates. 
650  0 Antibody-toxin conjugates. 
655  0 Electronic books. 
655  4 Electronic books. 
700 1  Wang, Jeffrey,|eeditor. 
700 1  Shen, Wei-Chiang,|d1942-|eeditor. 
700 1  Zaro, Jennica L.,|eeditor. 
710 2  SpringerLink|eissuing body. 
776 08 |iPrinted edition:|z9783319130804 
830  0 AAPS advances in the pharmaceutical sciences series ;
       |vvolume 17. 
830  0 Springer English/International eBooks 2015 - Full Set 
856 40 |uhttps://ezp.lib.unimelb.edu.au/login?url=http://
       link.springer.com/10.1007/978-3-319-13081-1|zConnect to 
       ebook (University of Melbourne only) 
990    Springer Full Set 2015 
990    Batch Ebook load (bud2) - do not edit, delete or attach 
       any records. 
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