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Author Wright, David Keith

Title Investigating biomarkers of traumatic brain injury with preclinical models

Published 2017


Location Call No. Status
Physical description 1 online resource
Thesis notes Thesis (PhD thesis)-- Anatomy and Neuroscience 2017
Summary Traumatic brain injury (TBI) results in a series of complex pathophysiological processes caused by external forces to the brain. The initial insult falls on a continuous spectrum from mild to severe and occurs in a heterogeneous patient population resulting in tremendous variability in the progression of secondary injury mechanisms. Currently, there are no biomarkers that can reliably, and objectively, assess these changes across the full spectrum of injury severity and time post-injury. This may be due, in part, to the inherent difficulty in studying TBI in the medical setting. As such, animal models have been developed as a practical platform for initial investigations into TBI and can provide a greater understanding of injury prognosis, leading to improved clinical care. These models are used here to assess the potential of neuroimaging, blood, and behavioural biomarkers to provide reliable and objective insight into the pathophysiological changes that occur following TBI. Significant contributions include evidence supporting a relationship between TBI and the later development of a motor neuron disease-like process, a comparison of diffusion-weighted imaging biomarkers in TBI, the identification of pathophysiological changes beyond the resolution of neurocognitive deficits that typically define recovery after mild TBI, and evidence that sex is an important consideration in adolescent repeated mild TBI.
Subject traumatic brain injury magnetic resonance imaging diffusion weighted imaging