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Title Neuronal and cognitive effects of oestrogens / [editors, Derek J. Chadwick and Jamie A. Goode].

Published Chichester ; New York : John Wiley, 2000.


Location Call No. Status
 UniM BioMed ST  612.62 NEUR    AVAILABLE
Physical description ix, 282 pages : illustrations ; 24 cm.
Series Novartis Foundation symposium ; 230.
Novartis Foundation symposium ; 230.
Bibliography Includes bibliographical references and index.
Contents Mechanism of oestrogen signalling with particular reference to the role of ER[beta] in the central nervous system / Eckardt Treuter, Margaret Warner, Jan-Ake Gustafsson 7 -- Oestrogen receptor function at classical and alternative response elements / Peter J. Kushner, David Agard, Wei-Jun Feng, Gabriela Lopez, Andrew Schiau, Rosalie Uht, Paul Webb, Geoffrey Greene 20 -- Nuclear receptor versus plasma membrane oestrogen receptor / Ellis R. Levin 41 -- Novel sites and mechanisms of oestrogen action in the brain / C. Dominique Toran-Allerand 56 -- Oestrogen modulation of noradrenaline neurotransmission / Allan E. Herbison, Sharon X. Simonian, Niren R. Thanky, R. John Bicknell 74 -- Oestrogen and the cholinergic hypothesis: implications for oestrogen replacement therapy in postmenopausal women / Robert B. Gibbs 94 -- Ovarian steroid action in the serotonin neural system of macaques / Cynthia L. Bethea, Chrisana Gundlah, Stephanie J. Mirkes 112 -- Oestrogen effects on dopaminergic function in striatum / Jill B. Becker 134 -- Oestrogen effects in olivo-cerebellar and hippocampal circuits / Sheryl S. Smith, Fu-Chun Hsu, Xinshe Li, Cheryl A. Frye, Donald S. Faber, Ronald S. Markowitz 155 -- Effects of oestradiol on hippocampal circuitry / Catherine S. Woolley 173 -- Oestrogen and cognitive function throughout the female lifespan / Barbara B. Sherwin 188 -- Neuroprotective effects of phenolic A ring oestrogens / Pattie S. Green, Shao-Hua Yang, James W. Simpkins 202 -- Female sex hormone oestrogen as neuroprotectant: activities at various levels / Christian Behl, Bernd Moosmann, Dieter Manthey, Stefanie Heck 221 -- Neurohormonal signalling pathways and the regulation of Alzheimer [beta]-amyloid metabolism / Sam Gandy, Suzana Petanceska 239 -- Oestrogens and dementia / Victor W. Henderson 254.
Summary Although normally thought of as a sex hormone, recent research has highlighted the numerous and significant effects that oestrogen has on the CNS, extending far beyond its important reproductive role. It has been shown that oestrogen acts as a neural growth factor with important influences on the survival, plasticity, regeneration and ageing of the mammalian brain. This exciting book brings together leading clinicians and researchers to discuss oestrogen's basic mechanisms of action, the extrahypothalmic brain regions it affects, and its influence on cognitive functions in animals and humans. Finally, recent research on the role of oestrogens in ageing and dementia, including the significance of oestrogen action in Alzheimer's disease, is discussed. The 15 papers contained in this book, together with the extensive discussion sessions that follow them, reveal much new and exciting work in this area, and identify promising new research directions.
Other author Goode, Jamie.
Chadwick, Derek.
Symposium on Neuronal and Cognitive Effects of Oestrogens (1999 : London, England)
Subject Estrogen -- Physiological effect -- Congresses.
Neuroendocrinology -- Congresses.
Neurohormones -- Congresses.
ISBN 0471492035 No price
0471492035 (alk. paper)