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Author Bueno, Ericka M.

Title Biologic foundations for skeletal tissue engineering [electronic resource] / Ericka M. Bueno, Julie Glowacki.

Published San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, c2011.


Location Call No. Status
Physical description 1 electronic text (viii, 210 p.) : ill., digital file.
Series Synthesis lectures on tissue engineering, 1944-0308 ; # 7
Synthesis digital library of engineering and computer science.
Synthesis lectures on tissue engineering, 1944-0308 ; # 7.
Notes Part of: Synthesis digital library of engineering and computer science.
Series from website.
Bibliography Includes bibliographical references (p. 127-208).
Contents 1. Introduction --
2. Structure and function of bone and cartilage tissue -- Bone -- Structure -- Function -- Mechanical properties -- Articular cartilage -- Structure -- Function -- Mechanical properties --
3. Development -- Intramembranous bone formation -- Endochondral bone formation -- Articular cartilage --
4. Responses to injury and grafting -- Bone -- Microfractures -- Bone fractures -- Fracture healing -- Distraction osteogenesis -- Comparison of post-natal fracture healing and skeletal embryogenesis -- Bone grafts, implants, and bone substitute materials -- Cartilage --
5. Clinical applications for skeletal tissue engineering -- Disorders in bone -- Focal deficiencies -- Systemic disorders of bone -- Cartilage -- Osteoarthritis -- Rheumatoid arthritis -- Osteochondritis dissecans -- Temporomandibular joint (TMJ) disorders --
6. Animal models -- Bone -- Biocompatibility -- Osteocompatibility -- Bone substitutes -- Clinical relevance -- Cartilage --
7. Tissue engineering principles for bone and cartilage -- Bone -- Scaffolds -- Bioactive factors -- Cells -- In vitro studies -- In vivo studies -- Cartilage -- Scaffolds -- Bioactive factors -- Cells -- In vitro studies -- In vivo studies --
8. Perspectives -- References -- Authors' biographies.
Restrictions Abstract freely available; full-text restricted to subscribers or individual document purchasers.
Summary Tissue engineering research for bone and joint applications entails multidisciplinary teams bringing together the needed expertise in anatomy, biology, biochemistry, pathophysiology, materials science, biomechanics, fluidics, and clinical and veterinary orthopedics. It is the goal of this volume to provide students and investigators who are entering this exciting area with an understanding of the biologic foundations necessary to appreciate the problems in bone and cartilage that may benefit from innovative tissue engineering approaches. This volume includes state-of-the-art information about bone and cartilage physiology at the levels of cell and molecular biology, tissue structure, developmental processes, their metabolic and structural functions, responses to injury, mechanisms of post-natal healing and graft incorporation, the many congenital and acquired disorders, effects of aging, and current clinical standards of care. It reviews the strengths and limitations of various experimental animal models, sources of cells, composition and design of scaffolds, activities of growth factors and genes to enhance histogenesis, and the need for new materials in the context of cell-based and cell-free tissue engineering. These building blocks constitute the dynamic environments in which innovative approaches are needed for addressing debilitating disorders of the skeleton. It is likely that a single tactic will not be sufficient for different applications because of variations in the systemic and local environments. The realizations that tissue regeneration is complex and dynamic underscore the continuing need for innovative multidisciplinary investigations, with an eye to simple and safe therapies for disabled patients.
Other formats Also available in print.
System notes Mode of access: World Wide Web.
System requirements: Adobe Acrobat Reader.
Notes Title from PDF t.p. (viewed on February 19, 2011).
Other author Glowacki, Julie.
Subject Tissue engineering.
Bone regeneration.
Cartilage -- Regeneration.
Fracture healing
Bone pathology
Cartilage pathology
Animal models
Cell-based tissue engineering
Cell-free tissue engineering
Growth factors
Differentiation factors
ISBN 9781608451739 (electronic bk.)
9781608451722 (pbk.)
Standard Number 10.2200/S00329ED1V01Y201101TIS007