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Title Cartilage. Volume 3, Repair strategies and regeneration / Susanne Grässel, Attila Aszódi, editors.

Published Cham, Switzerland : Springer, 2017.


Location Call No. Status
Physical description 1 online resource
Series Springer Biomedical and Life Sciences eBooks 2017 English+International
Contents Preface; Contents; List of Contributors; 1: Overview: State of the Art and Future Prospectives for Cartilage Repair; 1.1 Introduction; 1.1.1 Clinical Relevance and Needs of Cartilage Repair; 1.2 Cartilage Structure, Function, and Injuries; 1.2.1 Cartilage Structure; 1.2.2 Cartilage Injury; 1.2.3 Clinical Outcomes of Treatments; 1.3 Current Cartilage Repair Strategies; 1.3.1 Palliative Approach: Arthroscopic Debridement/Lavage; 1.3.2 Intrinsic Repair: Bone Marrow Stimulation Technique-Abrasion, Drilling, and Microfracture.
1.3.3 Whole Tissue Transplantation: Osteochondral Graft Transplantation1.3.4 Tissue-Engineered Cartilage; Autologous Chondrocyte Implantation/Transplantation (ACI/ ACT); 1.3.5 Total Joint Replacement; 1.4 New Strategies Under Investigation; 1.4.1 Cell-Based Therapies; Stem Cells; Stem Cell Types Relevant to Cartilage Repair; Signaling Factors: Stem Cell Differentiation and Cell Phenotype Maintenance; Allogeneic Chondrocytes; 1.4.2 Biomaterial Scaffolds for Cartilage Repair; Current Biomaterials and 3D Scaffolds. Major Concerns in Scaffold Design1.5 Unsolved Problems and Challenges in Cartilage Repair; 1.5.1 Tissue Integration; 1.5.2 Maintenance of Cell Phenotype; 1.5.3 Simplifying Surgical and Rehabilitation Procedures; 1.5.4 Prevention of OA Progress; Establishing Correct Joint Mechanical Environment; Rebuilding Subchondral Bone; Anti-Inflammatory Actions; References; 2: MSC Populations for Cartilage Regeneration; 2.1 Embryonic Origin of Chondroprogenitor Cells (CPCs); 2.2 In Vivo Presence of MSCs in Adult Joints; 2.2.1 Characteristics of MSCs In Vivo. Articular Cartilage-Derived Chondroprogenitor cells (CPCs) Bone Marrow-Derived MSCs (BMSCs); Synovium-Derived MSCs (SM-MSCs); Synovial Fluid-Derived MSCs (SF-MSCs); Infrapatellar Fat Pad-Derived MSCs (IF-MSCs); 2.2.2 Contribution to Repair by MSCs In Vivo; 2.3 MSCs In Vitro; 2.3.1 Articular Cartilage-Derived MSCs (AC-MSCs); 2.3.2 Bone Marrow-Derived MSCs (BMSCs); 2.3.3 Synovium-Derived MSCs (SM-MSCs); 2.3.4 Synovial Fluid-Derived MSCs (SF-MSCs); 2.3.5 Infrapatellar Fat Pad-Derived MSCs (IF-MSCs).
2.4 Manipulation of Joint Stem Cell Phenotype In Vitro by Growth FactorsReferences; 3: Chondrogenic Progenitor Cells and Cartilage Repair; 3.1 Osteoarthritis and Rheumatoid Arthritis; 3.2 Regeneration Attempts in Cartilage Tissue; 3.2.1 Mesenchymal Stem Cells and Osteoarthritis; 3.2.2 Mesenchymal Stem Cells and Rheumatoid Arthritis; 3.3 Chondrogenic Progenitor Cells; 3.3.1 Chondrogenic Progenitor Cells from Osteoarthritic Patients (CPCs); 3.3.2 Chondrogenic Progenitor Cells from Rheumatoid Arthritis Patients; 3.3.3 Meniscus Progenitor Cells (MPCs); References.
Bibliography Includes bibliographical references at the end of each chapters.
Summary In three Volumes this mini book series presents current knowledge and new perspectives on cartilage as a specialized yet versatile tissue. This third volume provides insight into current and future treatment strategies for repair of cartilage lesions. This book addresses Professors, researchers and PhD students who are interested in musculoskeletal and cartilage pathobiology and tissue-engineering.
Other author Grässel, Susanne, editor.
Aszódi, Attila, editor.
SpringerLink issuing body.
Subject Cartilage.
Cartilage -- Regeneration.
Electronic book.
Electronic books.
Variant Title Repair strategies and regeneration
ISBN 9783319533162 (electronic bk.)
3319533169 (electronic bk.)
9783319533148 (print)
Standard Number 10.1007/978-3-319-53316-2