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Table of Contents
 University of Melbourne Author 

Title Metabolomics tools for natural product discovery : methods and protocols / Edited by Ute Roessner and Daniel Anthony Dias.

Published New York : Humana Press, [2013].


Location Call No. Status
 UniM BioMed ST  574.88078 METH  v.1055    AVAILABLE
Physical description x, 311 pages : illustrations ; 27 cm.
Series Methods in molecular biology, 1064-3745 ; v. 1055
Methods in molecular biology (Clifton, N.J.) ; v.1055
Notes "Springer protocols" --Cover
Contents 1. Bryophytes: Liverworts, Mosses and Hornworts: Extraction and Isolation Procedures / Yoshinori Asakawa and Agnieszka Ludwiczuk -- 2. Plant Tissue Extraction for Metabolomics / Ute Roessner and Daniel Anthony Dias -- 3. Detection of Polar Metabolites through the use of Gas Chromatography: Mass Spectrometry / David P. De Souza -- 4. A Robust GC-MS Method for the Quantitation of Fatty Acids in Biological Systems / Nirupama Samanmalie Jayasinghe and Daniel Anthony Dias -- 5. A Workflow from Untargeted LC-MS Profiling to Targeted Natural Product Isolation / Damien L. Callahan and Candace E. Elliot -- 6. Lipidomics: Extraction Protocols for Biological Matrices / Thusitha Wasntha Thilanka Rupasinghe -- 7. Metabolite Analysis of Biological Fluids and Tissues by Proton Nuclear Magnetic Resonance Spectroscopy / John Robert Sheedy -- 8. NMR Spectroscopy: Structure Elucidation of Cycloelatenene A: A Natural Product Case Study / Sylvia Urban and Daniel Anthony Dias -- 9. NMR-Based Metabolomics: A Probe to Utilize Biodiversity / Lucia P. Santos Pimenta, Hye Kyong Kim, Robert Verpoorte, and Young Hae Choi -- 10. Extraction Protocol for Non-Targeted NMR and LC-MS Metabolomics-Based Analysis of Hard Coral and their Algal Symbionts / Benjamin R. Gordon, William Leggat, and Cherie Motti -- 11. Determination of Absolute Configuration Using Single Crystal X-ray Diffraction / Abigail L. Albright and Jonathan M. White -- 12. Natural Product Chemistry in Action: The Synthesis of Melatonin Metabolites K1 and K2 / Helmut M. Hügel and Oliver A.H. Jones -- 13. Discovery, Biosynthesis, and Rational Engineering of Novel Enterocin and Wailupemycin Polyketide Analogues / John A. Kalaitziz -- 14. Bioassays for Anticancer Activities / Janice McCauley, Ana Zivanovic, and D. Skropeta -- 15. Screening for Anti-Diabetic Activities / Rima Caccetta and Hani Al Salami -- 16. Screening for Antibacterial, Antifungal and Anti-Quorum Sensing Activity / Elisa J. Hayhoe and Enzo A. Palombo -- 17. Metabolomics and Dereplication Strategies in Natural Products / Ahmed Fares Tawfike, Christina Viegelmann, and RuAngelie Edrada-Ebel -- 18. Bridging the Gap: Basic Metabolomics Methods for Natural Product Chemistry / Oliver A.H. Jones and Helmut M. Hugel -- 19. Strategies in Biomarker Discovery. Peak Annotation by MS and Targeted LC-MS Micro-Fractionation for de novo Structure Identification by Micro-NMR / Philippe J. Eugster, Gaetan Glauser, and Jean-Luc Wolfender -- 20. Statistical Analysis of Metabolomics Data / Alysha M. De Livera, Moshe Olshansky, and Terence P. Speed
Summary A summary of recent developments occurring in natural product chemistry, which is transitioning to modern day metabolomics as a result of the advent of comprehensive analytical platforms and sensitive analytical instrumentation. This book seeks to serve both professionals and research students with its well-honed methodologies for natural product isolation, biomrker discovery, dereplication, biological assays and comprehensive metabolomic platforms available for high-throughput analyses.
Other formats Also available online. Publisher description:
Other author Dias, Daniel Anthony, editor of compilation
Roessner, Ute, editor of compilation
Subject Natural products -- Laboratory manuals.
Metabolites -- Laboratory manuals.
Data mining -- Laboratory manuals.
ISBN 9781627035767