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E-RESOURCE

Title Mass spectrometry and genomic analysis [electronic resource] / edited by J. Nicholas Housby.

Published Dordrecht ; Boston : Kluwer Academic Publishers, 2001.

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Location Call No. Status
 UniM INTERNET resource    AVAILABLE
Physical description 1 online resource (xv, 149 pages) : illustrations.
Series Focus on structural biology ; v. 2
Focus on structural biology ; v. 2.
Bibliography Includes bibliographical references and index.
Contents Single-nucleotide polymorphism analysis by MALDI-TOF mass spectrometry / T.J. Griffin, L.M. Smith -- SNP genotyping by MALDI-TOF mass spectrometry / L.A. Haff, A.C. Belden, L.R. Hall, P.L. Ross, I.P. Smirnov -- MASSARRAY(tm): highly accurate and versatile high throughput analysis of genetic variations / Hubert K诳ter -- The GOOD assay / S. Sauer, D. Lechner, I.G. Gut -- Microchip analysis of DNA sequence by contiguous stacking of oligonucleotides and mass spectrometry / P.H. Tsatsos, V. Vasiliskov, A. Mirzabekov -- Short oligonucletide mass analysis (SOMA): and ESI-MS application for genotyping and mutation analysis / P.E. Jackson, M.D. Friesen, J.D. Groopman -- Proteomics and mass spectrometry: some aspects and recent developments / W.V. Bienvenut, M. M赬ler, P.M. Palagi, E. Gasteiger, M. Heller, E. Jung, M. Giron, R. Gras, S. Gay, P.A. Binz, G.J. Hughes, J.C. Sanchez, R.D. Appel, D.F. Hochstrasser.
Summary The human genome project is set to revolutionise health care and medicine in the near future. The genetic make up of each individual gives clues as to the genetic factors that predispose one to a particular genetic disease. Single Nucleotide Polymorphisms (SNPs), single base changes in the nucleotide DNA sequence of individuals, are thought to be the main cause of genetic variation. By comparing patterns of SNP allele frequencies between disease affected and control populations, disease associated SNPs can be identified and potential disease gene(s) located. These types of study necessitate genotyping of thousands of SNPs which requires the use of powerful, high throughput, systems of analysis. Mass spectrometry is fast becoming the preferred technology for this type of high throughput analysis. This book contains a collection of descriptions of some of the most outstanding advances in the field of mass spectrometry from which, I hope, the reader will be able to learn both the principles and the most up to date methods for its use in genomic analysis. It covers the general principles of the technologies and more in depth detailed descriptions for more academic reading and information. Audience: Whether you are a student, a post-doctoral researcher or experienced MS user, this book will be a stimulating addition to the analytical arena of mass spectrometry and genomic analysis.
Notes Description based on print version record.
Other author Housby, J. Nicholas.
Subject Nucleotide sequence.
Mass spectrometry.
Genomes -- Analysis.
SCIENCE -- Life Sciences -- Genetics & Genomics.
Electronic books.
ISBN 0306475952 (electronic bk.)
9780306475955 (electronic bk.)
0792371739
9780792371731