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LEADER 00000nam  2200421 a 4500 
003    MiAaPQ 
006    m     o  d |       
007    cr cn||||||||| 
008    120904s2013    njuad   sb    001 0 eng d 
010    |z2012027157 
019    PQacadEBC1104493 
020    |z9781118054178 (hardback) 
020    |z9781118495216 (e-book) 
035    (OCoLC)823389931 
035    (MiAaPQ)EBC1104493 
035    (Au-PeEL)EBL1104493 
035    (CaPaEBR)ebr10648817 
035    (CaONFJC)MIL429061 
040    MiAaPQ|cMiAaPQ|dMiAaPQ 
050  4 QD79.C454|bH93 2013 
082 04 543/.84|223 
245 00 Hydrophilic interaction chromatography|h[electronic 
       resource] :|ba guide for practitioners /|cedited by 
       Bernard A. Olsen, Brian W. Pack. 
260    Hoboken, N.J. :|bJohn Wiley & Sons, Inc.,|c2013. 
300    xvi, 313 p. :|bill. (some col.). 
490 1  Chemical analysis : a series of monographs on analytical 
       chemistry and its applications ;|vv. 177 
504    Includes bibliographical references and index. 
505 8  Machine generated contents note:  Chapter 1. Separation 
       Mechanisms in Hydrophilic Interaction Chromatography 1.1 
       Introduction 1.2 Historical Background. Recognition of the
       contribution of partition, ion exchange and reversed-phase
       interactions to the retention process 1.3 Recent studies 
       on the contributory mechanisms to HILIC retention 1.3.1 
       Overview 1.3.2 Contribution of adsorption and partition to
       HILIC separations 1.3.3 Further studies on the 
       contribution of ionic retention in HILIC 
       Introduction Mobile phase considerations for the 
       separation of ionogenic compounds Ionisation 
       state of the column as a function of pH 
       Quantitation of ionic retention effects on different 
       columns 1.3.4 Reversed-phase retention on bare silica 
       1.3.5 Electrostatic Repulsion Hydrophilic Interaction 
       Chromatography (ERLIC)- a new separation mode in HILIC. 
       1.4 Conclusions Chapter 2. Stationary Phases for HILIC 2.1
       Introduction 2.2 HILIC stationary phases 2.2.1 
       Underivatized silica Totally porous silica 
       particles Superficially porous (core shell) silica
       particles Monolithic silica Ethylene 
       Bridged Hybrids (BEH) 2.2.2 Derivatized silica 
       Neutral derivatized silica Zwitterionic 
       derivatized silica Positively charged derivatized 
       silica Negatively charged derivatized silica 2.2.3
       Non-silica phases Amino phases Sulfonated 
       S-DVB phases 2.3 Commercial HILIC phases 2.3.1 Efficiency 
       comparison 2.3.2 Retention and selectivity comparisons 2.4
       Conclusions Chapter 3. HILIC Method Development 3.1 
       Introduction 3.2 General method development considerations
       3.2.1 Method objectives 3.2.2 Sample consideration 3.2.3 
       Systematic method development 3.3 Method development 
       strategies 3.3.1 Systematic approach to column screening 
       3.3.2 Optimization of method parameters Final 
       column selection Organic solvents Mobile 
       phase pH Buffer types and concentration 
       Column temperature Sample solvents 3.4 Detection 
       for HILIC methods 3.4.1 Mass Spectrometry detector (MS) 
       3.4.2 Charged aerosol detector (CAD) 3.5 Conclusions 
       Chapter 4. Pharmaceutical Applications of Hydrophilic 
       Interaction Chromatography 4.1 Introduction 4.1.1 
       Definition of the problem 4.1.2 Selection of conditions 
       4.1.3 Validation of the method 4.1.4 General references 
       4.2 Determination of Counterions 4.2.1 Salt selection and 
       options for counterion determination 4.2.2 Specific 
       counterion analysis 4.2.3 Counterion screening with 
       gradient elution 4.2.4 Suitable reference standards for 
       counterion analysis 4.3 Main Component Methods 4.3.1 
       Potency/assay methods 4.3.2 Equipment cleaning 
       verification assays 4.3.3 Dissolution methods 4.4 
       Determination of Impurities 4.4.1 Impurity screening and 
       orthogonal separations 4.4.2 Impurity identification 4.4.3
       Specific impurity determination Pyrimidines, 
       purines, nucleosides Hydrazines with ethanol as 
       weak solvent Neutral and charged polar impurities 
       in a drug substance Polar basic compounds and 
       impurities 4.4.4 Statistical design of experiments (DOE) 
       for optimization 4.5 Excipients 4.5.1 Parenteral and 
       solution formulations 4.5.2 Tablets, capsules and 
       inhalation products 4.5.3 Sugars 4.5.4 Stabilizers and 
       antioxidants 4.6 Chiral Applications 4.6.1 Chiral 
       selectors and HILIC Cyclodextrins 
       Macrocyclic antibiotics Chiral crown ethers Cyclofructans 4.6.2 Conclusions for chiral 
       separations 4.7 Conclusions Chapter 5. Hydrophilic 
       Interaction Chromatography (HILIC) for Drug Discovery 5.1 
       Drug Discovery Model 5.2 HILIC Applications for in vitro 
       Biology 5.2.1 Biological screening and hit finding
       Target selection and assay validation High-
       throughput screening 5.2.2 New drug discovery strategies 
       5.3 HILIC Applications and Advances for Discovery 
       Chemistry 5.3.1 Lead identification 5.3.2 Lead 
       optimization ADME profile Biopharmaceutics Chiral purity 5.3.3 Candidate selection 5.4 
       Practical Considerations 5.5 Conclusions Chapter 6. 
       Advances in Hydrophilic Interaction Chromatography (HILIC)
       for Biochemical Applications 6.1 Introduction 6.2 
       Carbohydrates 6.2.1 Mono- and disaccharides 6.2.2 
       Oligosaccharides and polysaccharides 6.2.3 Glycans
       Glycan and glycopeptide analysis HILIC for sample 
       enrichment 6.3 Nucleobases and Nucleosides 6.4 
       Oligonucleotides 6.5 Amino Acids and Peptides 6.6 Proteins
       6.7 Phospholipids 6.8 Conclusions Chapter 7. HILIC-MS for 
       Targeted Metabolomics and Small Molecule Bioanalysis 7.1 
       Introduction 7.2 The role of HILIC-MS in targeted 
       metabolomics versus other LC modes 7.3 Strategies for 
       method development based on retention behavior of targeted
       metabolites on HILIC stationary phases 7.3.1 Retention 
       behavior of metabolites on HILIC stationary phases 7.3.2 
       Robustness, mobile phase compositions, and matrix effects 
       7.4 Summary Chapter 8. HILIC for Food, Environmental, and 
       Other Applications 8.1 Introduction 8.2 Food applications 
       for HILIC 8.2.1 Review of HILIC analytical methods for 
       food analysis Sample preparation in HILIC methods 
       applied to food matrices HILIC methods applied to 
       food matrices: chromatographic parameters and detection 
       8.2.2 Selected detailed examples of HILIC applications in 
       food analysis Melamine (MEL) and cyanuric acid 
       (CYA) Water soluble vitamins Seafood and 
       other toxins 8.3 Environmental and other applications of 
       HILIC 8.3.1 Review of environmental applications based on 
       the stages of method development 8.3.2 Selected detailed 
       examples of environmental and other HILIC applications Metals and their related organic compounds
       Pharmaceutical compounds in aqueous environmental samples Other applications 8.4 Conclusions Chapter 9. 
       Theory and Practice of Two-Dimensional Liquid 
       Chromatography Separations Involving the HILIC Mode of 
       Separation 9.1 Fundamentals of multi-dimensional liquid 
       chromatography 9.1.1 Scope 9.1.2 Potential advantages of 
       two-dimensional separations over conventional separations 
       9.1.3 Modes of 2D separation Offline fraction 
       transfer Online fraction transfer 
       Conceptual comparison of different 2D separation modes 
       9.1.4 Undersampling 9.1.5 Orthogonality 9.2 
       Complementarity of HILIC selectivity to other separation 
       modes 9.3 Instrumentation and Experimental Considerations 
       9.3.1 Online versus offline 2DLC Offline 2DLC Online 2DLC 9.3.2 Dealing with solvent 
       incompatibility Partial mobile phase evaporation Consideration of fraction transfer volume relative
       to the second dimension column volume On-column 
       focusing 9.3.3 Fast Separations General 
       considerations for fast LC separations Fast HILIC 
       separations 9.4 Applications 9.5 The future of HILIC 
       separations in 2DLC. 
520    "This book provides background information, guidance for 
       method development, and a discussion of applications in 
       the field of hydrophilic interaction chromatography 
       (HILIC.) The book serves as a valuable reference tool for 
       scientists confronted with an analysis problem involving 
       polar compounds to determine if HILIC would be a good 
       choice to pursue and helps them in choosing initial 
       experimental conditions. The book gives a detailed 
       description of the HILIC retention mechanisms and specific
       information regarding application areas spanning a wide 
       range of industries.Topics include: HILIC retention 
       mechanisms, Stationary Phases for HILIC, HILIC Method 
       Development, Pharmaceutical and Other Applications of 
       HILIC, HILIC for Drug Discovery, HILIC in Two-Dimensional 
       Separations"--|cProvided by publisher. 
533    Electronic reproduction. Ann Arbor, MI : ProQuest, 2016. 
       Available via World Wide Web. Access may be limited to 
       ProQuest affiliated libraries. 
650  0 Hydrophilic interaction liquid chromatography. 
655  4 Electronic books. 
700 1  Olsen, Bernard A.,|d1953- 
700 1  Pack, Brian W.,|d1970- 
710 2  ProQuest (Firm) 
830  0 Chemical analysis ;|vv. 177. 
856 40 |u
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