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Author Balasuriya, Balasuriya Mudiyanselage Gayathri Kumari, author.

Title Sexual dimorphic effect of Cholera Toxin on colonic motility / B.M. Gayathri Kumari Balasuriya

Published [Parkville, Victoria] : University of Melbourne, 2015


Location Call No. Status
 UniM Bund SpC/T  BALASUR  2015    NOT FOR LOAN
Physical description xxiii, 216 leaves, bound : illustrations (some colored) ; 30 cm
Notes Typescript.
Summary Diarrhea is a combination of hypersecretion and increased gut motility. Bacterial toxins such as cholera toxin (CT) are a main cause of diarrhea around the world creating life threatening outbreaks. Although the effect of CT on hypersecretion is widely studied, its effect on motility remains largely unexplored. At the same time incidence of diarrhea, constipation and other GI tract related issues appear to be more frequent among females compared to men. GI complications are often reported with fluctuations in sex steroid hormone levels, such as pregnancy, menopause and the different stages of the menstrual cycle, indicating a direct relationship between sex hormones and functioning of the gastrointestinal tract. Therefore the main aim of this project was to evaluate the effect of CT on intestinal motility using both female and male C57Bl/6 mice. -- excerpt from Abstract
Bibliography Includes bibliographical references ( leaves 173-215)
Thesis notes Thesis (Ph.D.)-- University of Melbourne, Department of Physiology, Faculty of Medicine, Dentistry and Health Sciences, 2016.
Subject Diarrhea -- Etiology
Sex hormones -- Effect on GI tract of
Cholera toxin, enteric nervous system, estrogen, serotonin, colonic motility