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Cover Art
PRINTED BOOKS
Author Orwoll, Eric S.

Title Osteoporosis in men : the effects of gender on skeletal health.

Published Boston, Mass. ; London : AP Professional, 1999.

Copies

Location Call No. Status
 UniM BioMed ST  616.716 ORWO    AVAILABLE
Physical description 500 pages ; 23 cm
Contents Chapter 1 Epidemiology of Fractures / L. Joseph Melton III -- II. Effects of Age 2 -- III. Effects of Gender 3 -- IV. Effects of Race 4 -- V. Effects of Geography 6 -- VI. Secular Trends 7 -- VII. Public Health Implications 8 -- Chapter 2 Economic Impact of Fractures / Anna N. A. Tosteson -- II. Economic Evaluation 16 -- III. Definition of Costs 17 -- IV. Review of Studies 18 -- V. Summary of Findings 24 -- VI. Directions for Future Research 25 -- Chapter 3 Hip and Vertebral Fractures / Frazer H. Anderson, Cyrus Cooper -- II. Demographic Factors 30 -- III. Gender-Specific Factors 31 -- IV. Factors Affecting Case Definition 34 -- V. Social and Economic Factors 36 -- VI. Falls 39 -- VII. Consequencs of Osteoporotic Vertebral and Femoral Fracture 41 -- VIII. Intervention 42 -- IX. Future Trends 44 -- Chapter 4 Outcomes and the Personal Impact of Osteoporosis / Deborah T. Gold -- I. Introduction 51 -- II. Men and Osteoporosis: Where Do We Start to Understand Outcomes? 58 -- III. Commentary 59 -- Chapter 5 Accumulation of Bone Mass during Childhood and Adolescence / Vicente Gilsanz -- II. Techniques for Bone Measurements in Children 66 -- III. Peak Bone Mass 67 -- IV. Age-Related Changes in the Axial and Appendicular Skeletons 68 -- V. Nutrition 70 -- VI. Physical Activity 71 -- VII. Genetics 73 -- VIII. Gender 74 -- IX. Race 77 -- Chapter 6 Bone Size, Mass, and Volumetric Density: The Importance of Structure in Skeletal Health / Ego Seeman -- II. Comparing Men and Women of Different Races 88 -- III. Changes in Bone Size, Mass, and Volumetric Density during Aging 94 -- IV. Comparing Men with and without Fractures 100 -- Chapter 7 Aging and Changes in Cortical Mass and Structure / R. Bruce Martin -- II. Basic Mechanical Considerations in Diaphyseal Modeling 112 -- III. Mechanical Role of Remodeling 114 -- IV. Gender Differences in Modeling during Puberty 114 -- V. Animal Studies of the Effects of Sex Hormones on Modeling 116 -- VI. Male Hypogonadism 118 -- VII. Remodeling, Fatigue Damage, and Mechanical Properties in the Aging Skeleton 119 -- VIII. Compensatory Modeling in the Aging Skeleton 121 -- IX. Neck of the Femur 123 -- X. Summary and Research Directions 125 -- Chapter 8 Skeletal Effects of Exercise in Men / Belinda Beck, Robert Marcus -- II. Definitions 130 -- III. Male Skeleton--Why Care about It? 130 -- IV. Response of Bone to Loading--Fundamental Aspects 132 -- V. Translating Theory into Practice--Exercise and Bone 135 -- VI. Unloading Bone--In Brief 145 -- VII. Hormonal Factors 146 -- VIII. Sex Comparison of Exercise Effect on Bone 147 -- IX. Maintaining Bone Mass--Exercise Prescription 148 -- Chapter 9 Insulin-like Growth Factors and Bone: Implications for the Pathogenesis and Treatment of Osteoporosis / Clifford J. Rosen -- II. Physiology of the IGFs 158 -- III. IGFs and Their Role in Acquisition and Maintenance of Adult Bone Mass 167 -- Chapter 10 Age-Related Changes in Mineral Metabolism / Bernard P. Halloran, Daniel D. Bikle -- II. Regulation of Mineral Metabolism 180 -- III. Human Aging 180 -- IV. Aging and Mineral Metabolism 181 -- Chapter 11 Calcium and Vitamin D Nutrition / Bess Dawson-Hughes -- II. Calcium and Vitamin D Metabolism 198 -- III. PTH Response to Calcium and Vitamin D 199 -- IV. Calcium, Vitamin D, and Bone Turnover 200 -- V. Calcium, Vitamin D, and the Skeleton 202 -- VI. Recommended and Usual Intakes 205 -- Chapter 12 Androgens and Bone: Basic Aspects / Kristine M. Wiren, Eric S. Orwoll -- II. Mechanisms of Androgen Action in Bone: The Androgen Receptor 212 -- III. Effects of Androgens on the Proliferation and Differentiation of Osteoblastic Cells 217 -- IV. Interaction with Other Factors to Modulate Bone Formation and Resorption 218 -- V. Direct Effects of Androgens on Other Cell Types in Bone in Vitro 222 -- VI. Metabolism of Androgens in Bone--Aromatase and 5a-Reductase Activities 223 -- VII. Androgen Effects on Bone: Animal Studies 227 -- Chapter 13 Androgens and Bone: Clinical Aspects / Eric S. Orwoll -- II. Puberty 248 -- III. Estrogens versus Androgens in Puberty 251 -- IV. Age-Related Declines in Androgen Levels in Adult Men: Contribution to Bone Loss 252 -- V. Estrogens in Adult Men 254 -- VI. Hypogonadism in Adult Men 254 -- VII. Androgen Therapy: Potentially Useful Androgen Effects 257 -- VIII. Androgen Replacement in Adolescent Hypogonadism 259 -- IX. Androgen Replacement in Hypogonadal Adult Men 260 -- X. Androgen Replacement in Aging Men 267 -- XI. Androgen Therapy in Eugonadal Men 268 -- XII. Androgen Therapy in Secondary Forms of Metabolic Bone Disease in Men 268 -- XIII. Therapy with Other Androgens 269 -- XIV. Research Directions 269 -- Chapter 14 Estrogens and Bone Health / Patrick M. Doran, Russell T. Turner, B. Lawrence Riggs, Sundeep Khosla -- II. Cellular and Molecular Effects of Estrogen on Bone 276 -- III. Effects of Estrogen on Laboratory Animals 280 -- IV. Effects of Estrogen on Human Bone Metabolism and Calcium Homeostasis 286 -- Chapter 15 Age-Related Changes in Bone Remodeling / Torben Steiniche, Erik F. Eriksen -- I. Introduction 299 -- II. Bone Mass and Structure 303 -- III. Age-Related Changes in Bone Turnover (Activation Frequency) and Differences between Men and Women 305 -- Chapter 16 Trabecular Microarchitecture and Aging / Lis Mosekilde -- II. Human Spine 314 -- III. Structural Determinants of Vertebral Strength and Mechanisms for Loss of Strength with Age 317 -- IV. Gender-Specific Differences in the Aging Process 324 -- V. Role of These Age-Related Changes in Fracture Causation--Osteoporosis 327 -- VI. Osteophyte Formation and Bone Structure and Strength 327 -- VII. Avenues for Future Research 329 -- Chapter 17 Risk Factors for Low Bone Mass in Men / Tuan V. Nguyen, John A. Eisman -- II. Prevalence of Osteoporosis and Low Bone Mass 336 -- III. Incidence of Fractures 338 -- IV. Risk Factors for Fractures 341 -- V. Bone Mineral Density in Men 344 -- VI. Summary and Future Directions 352 -- Chapter 18 Risk Factors for Fractures in Men / Jane A. Cauley, Joseph M. Zmuda -- II. Summary and Future Directions 386 -- Chapter 19 Idiopathic Osteoporosis in Men / John P. Bilezikian, Etah S. Kurland, Clifford J. Rosen -- II. Definition 396 -- III. Characteristics of Idiopathic Osteoporosis in Men 397 -- IV. Etiological Considerations 401 -- V. Clinical Approach and Management 409 -- VI. Future Directions 411 -- Chapter 20 Glucocorticoids and Osteoporosis / Ian R. Reid -- II. Clinical Presentation 418 -- III. Pathophysiology 420 -- IV. Patient Evaluation 423 -- V. Management 425 -- VI. Research Directions 431 -- Chapter 21 Alcohol / Robert F. Klein -- II. Alcohol-Induced Osteoporotic Fractures 438 -- III. Alcohol-Induced Osteopenia 439 -- IV. Potential Mechanisms of Alcohol-Induced Bone Disease 443 -- V. Therapy of Alcohol-Induced Bone Disease 454 -- Chapter 22 Hypercalciuria and Bone Disease / Joseph E. Zerwekh -- II. Primary Mechanisms of Hypercalciuria 464 -- III. Potential Mechanisms for the Findings of Concomitant Hypercalciuria and Osteoporosis in Men 467 -- IV. Prevalence and Forms of Hypercalciuria in Men with Osteoporosis 472 -- V. Clinical Evaluation 475 -- VI. Therapeutic Considerations in the Hypercalciuric Osteoporotic Male 476 -- Chapter 23 Secondary Causes of Osteoporosis / Peter R. Ebeling -- I. Glucocorticoid-Induced Osteoporosis 483 -- II. Pulmonary Disease and Immunosuppressive Drugs 485 -- III. Hypogonadism 486 -- IV. Alcohol and Osteomalacia 489 -- V. Tobacco 490 -- VI. Gastrointestinal Disease 491 -- VII. Hypercalciuria 493 -- VIII. Anticonvulsants 493 -- IX. Pernicious Anemia 494 -- X. Thyrotoxicosis and Thyroidectomy 494 -- XI. Hyperparathyroidism 494 -- XII. Immobilization 495 -- XIII. Osteogenesis Imperfecta 495 -- XIV. Homocystinuria 495 -- XV. Neoplastic Disease (Multiple Myeloma, Lymphoma) 496 -- XVI. Ankylosing Spondylitis and Rheumatoid Arthritis 496 -- XVII. Systemic Mastocytosis 497 -- Chapter 24 Assessment of Bone Mass in Men / Philip D.
Ross, Antonio Lombardi, Debra Freedholm -- II. Clinical Interpretation of BMD 506 -- III. Techniques for Measuring Bone Mineral Density 507 -- IV. Age-Related Changes in Bone Mass 512 -- V. Relation between BMD and Fracture Risk 516 -- VI. Future Research Directions 522 -- Chapter 25 Clinical Evaluation of Osteoporosis in Men / Eric S. Orwoll -- II. Characteristics of Men at Risk 528 -- III. Clinical Approach to Osteoporosis in Men 532 -- IV. Differential Diagnosis 536 --
V. Initial Evaluation of Osteoporosis: History, Physical, and Routine Biochemical Measures 537 -- VI. Evaluation of the Patient with Unexplained Osteoporosis 538 -- VII. Falls 539 -- VIII. Discussion of Diagnostic Measures of Particular Interest 539 -- Chapter 26 Prevention and Therapy of Osteoporosis in Men / Eric S. Orwoll -- II. Prevention 554 -- III. Therapy 557.
Summary Osteoporosis in men is an important clinical problem that has received little attention, both in the medical arena and from the general public. Although the condition affects a higher percentage of women, it is estimated that two million men in the U.S. have osteoporosis, and three million more are at risk. A lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated.
Osteoporosis in Men is the first book to explore this issue in depth. This groundbreaking text brings together eminent investigators and clinicians who interpret developments in this emerging field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention, and therapy. It is an essential reference for researchers, students, and clinicians in bone-related disciplines.
Subject Osteoporosis.
ISBN 0125286406 £59.95