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Author Klein, William L., (Northwestern University, USA), speaker.

Title Targeting Aß oligomers : a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease / William L. Klein.

Published London : Henry Stewart Talks, 2014.


Location Call No. Status
Physical description 1 online resource (1 streaming video file (68 minutes) : color, sound).
polychrome rdacc
Series Drug discovery and development in the neurosciences.
Henry Stewart talks. Biomedical & life sciences collection. Drug discovery and development in the neurosciences.
Notes Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.
Restrictions Access restricted to subscribers.
System notes Mode of access: World Wide Web.
System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v2.1+, iPhone 4+ (iOS v5.x+), iPad 2+ (iOS v5.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+.
Subject Alzheimer's disease -- Chemotherapy.
Alzheimer's disease -- Diagnosis.
Alzheimer's disease -- Pathogenesis.
Amyloid beta-protein.
Nervous system -- Degeneration.
Variant Title Amyloid beta oligomers : pathogenic ligands that attack dendritic spines.
Aß oligomers : pathogenic ligands that attack dendritic spines.
Targeting AB oligomers.
Targeting amyloid beta oligomers.
Publisher Number 3594 Henry Stewart Talks