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Book Cover
Author Kingston, Robert (Harvard University, USA), speaker.

Title Maintaining the silenced state of master regulatory genes during development / Bob Kingston.

Published London : Henry Stewart Talks, 2014.


Location Call No. Status
Physical description 1 online resource (1 streaming video file (54 minutes) : color, sound).
polychrome rdacc
Series Epigenetics, chromatin, transcription and cancer.
Henry Stewart talks. Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.
Notes Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents Contents: Gene repression in cell division -- Early homeotic gene expression patterns -- The polycomb group -- Mutants of polycomb fail to maintain repression -- Transcriptional memory -- Core functional PcG complexes -- Regulation of PRC2 in drosophila and humans -- PRC2 core subunits in humans -- Prominent modifications that can occur -- Chromodomains bind H3 tail marks -- Differential chromodomain binding -- Targeting of the PcG complexes -- Drosophila PREs are bound by PHO -- Mechanisms involved in targeting -- Mammalian HOX clusters are a key PRC1 target -- Human D11.12 is similar to fly PREs -- CpG islands and long non-coding RNAs -- Small RNAs specifying repression -- Noncoding RNAs influence chromatin structure -- Mode of repression -- How are genes silenced? -- PRC1 in compaction and ubiquitylation -- Nucleosome dynamics -- Characteristics of the compaction domain -- Gene silencing by chromatin compaction -- The SIR complex and mating type silencing -- Structural rearrangements in NCP and BAH -- Folding events in Sir3 BAH/NCP complex -- The nucleosome as a silencing machinery -- Epigenetic memory.
Restrictions Access restricted to subscribers.
System notes Mode of access: World Wide Web.
System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v2.1+, iPhone 4+ (iOS v5.x+), iPad 2+ (iOS v5.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+.
Subject Chromosomal proteins.
Developmental genetics.
Gene silencing.
Genetic regulation.
Publisher Number 3513 Henry Stewart Talks