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Author Shaw, Pamela J., speaker.

Title Oxidative stress in ALS / Pam Shaw.

Published London : Henry Stewart Talks, 2007.


Location Call No. Status
Physical description 1 streaming video file (58 minutes) : digital, mono, SWF file, sound, colour.
polychrome rdacc
Series Free radicals and the oxygen paradox : oxidative stress in biology, aging and disease.
Henry Stewart talks. Biomedical & life sciences collection. Free radicals and the oxygen paradox : oxidative stress in biology, aging and disease.
Notes Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents Contents: Key facts -- The normal human motor system -- Motor neurone disease: clinical consequences -- Spared motor neurone groups -- Prognosis -- Features of motor neurones which may underlie selective vulnerability -- Complex and multifactorial disease -- Genetic factors -- SOD1 mutations -- Potential mechanisms of neuronal oxidative stress -- Sources of intracellular oxidative stress -- Mitochondrial free radical production -- ROS -- Evidence for the role of oxidative stress in ALS -- NSC34 cell model -- G93A mutant SOD1 -- Oxidative stress in human ALS -- Major pathogenetic factors -- Glutamate -- Excitotoxicity -- Mitochondrial dysfunction -- Potential mechanisms of action of antioxidant drugs -- Clinical trials.
Restrictions Access restricted to subscribers.
System notes Mode of access: World Wide Web.
System requirements: Operating System: PC Windows 2000+, Mac OSX+ 3.2. Browser Compatibility: IE6+, Firefox 2+, Opera 9+, Safari 2+ 3.3. Browser settings: enable JavaScript, enable popups from the Henry Stewart Talks site. 3.4. Required Browser Plugins & Viewers: Adobe (Macromedia) Flash Player 7+, Adobe Acrobat Reader 6.0+.