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Title Human neural stem cells : from generation to differentiation and application / Leonora Buzanska, editor.

Published Cham, Switzerland : Springer, [2018]


Location Call No. Status
Physical description 1 online resource.
Series Results and problems in cell differentiation ; 66
Results and problems in cell differentiation ; 66.
Springer Biomedical and Life Sciences eBooks 2018 English+International
Bibliography Includes bibliographical references.
Contents Part I. Derivation and-or generation of human neural stem cells: Derivation of neural stem cells from the developing and adult human brain / Claire M. Kelly and Maeve A. Caldwell -- Human somatic stem cell neural differentiation potential / David J. Eve [and four others] -- Neural stem cells derived from human-induced pluripotent stem cells and their use in models of CNS injury / Pavla Jendelova, Eva Sykova, and Slaven Erceg -- Generation of human neural stem cells by direct phenotypic conversion / Daekee Kwon, Hee-Jin Ahn, and Kyung-Sun Kang -- Part II. Differentiation and underlying mechanisms: Epigenetic regulation of human neural stem cell differentiation / Mizuki Honda, Kinichi Nakashima, and Sayako Katada -- Induced pluripotent stem cells reveal common neurodevelopmental genome deprograming in schizophrenia / Sridhar T. Narla [and four others] -- Genome editing in human neural stem and progenitor cells / Raul Bardini Bressan and Steven M. Pollard -- Brain organoids : expanding our understanding of human development and disease / L. B. Chuye [and nine others] -- Bioengineering of the human neural stem cell niche : a regulatory environment for cell fate and potential target for neurotoxicity / Leonora Buzanska, Marena Zychowicz, and Agnieszka Kinser-Ovaskainen -- Part III. Therapeutic potential of human neural stem cells: Updates on human neural stem cells : from generation, maintenance, and differentiation to applications in spinal cord injury research / Yang D. Teng [and six others] -- Human neural stem cells for ischemic stroke treatment / Zaal Kokaia and Vladimer Darsalia -- Modeling complex neurological diseases with stem cells : a study of bipolar disorder / Cameron D. Pernia [and six others] -- Neural stem cell dysfunction in human brain disorders / Ewa Liszweska and Jack Jaworski -- Human fetal neural stem cells for neurodegenerative disease treatment / Daniela Ferrari [and three others].
Summary This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.
Other author Buzanska, Leonora, editor.
SpringerLink issuing body.
Subject Neural stem cells.
Electronic books.
ISBN 9783319934853 (electronic bk.)
3319934856 (electronic bk.)
9783319934860 (print)
Standard Number 10.1007/978-3-319-93485-3