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PRINTED BOOKS

Title The nociceptive membrane / edited by Uhtaek Oh.

Published Amsterdam ; Boston : Elsevier, [publisher not identified], [2006]
©2006

Copies

Location Call No. Status
 UniM BioMed  612.88 NOCI    AVAILABLE
Physical description xiv, 472 pages : illustrations ; 24 cm.
Series Current topics in membranes ; v. 57.
Current topics in membranes ; v. 57.
Bibliography Includes bibliographical references and index.
Contents Chapter 1 Historical Evolution of Pain Concepts / Manfred Zimmermann -- II Pain: A Function of Brain Matter in the 17th Century 2 -- III Physics and Pseudophysics in Pain Treatment of the 18th Century 4 -- IV Discoveries in the 19th Century Relating to Pain 7 -- V Challenges and Changing Pain Concepts during the 20th Century 14 -- Chapter 2 History of Ion Channels in the Pain Sensory System / J. Szolcsanyi, G. Petho -- II TRPV1/VR1 Capsaicin Receptor 23 -- III Voltage-Gated Na[superscript +] Channels 38 -- IV Nicotinic Acetylcholine Receptors 51 -- V Serotonin Ionotropic Receptor 52 -- VI Glutamate Ionotropic Receptors, Proton-Gated Ion Channels (ASIC2, ASIC3), and P2X Purinoceptors 53 -- VII Initiation of Impulses at Nociceptors 55 -- Chapter 3 Nociceptive Membrane: Historical Overview / William D. Willis -- II Nociceptive Transduction 77 -- III Sensitization of Nociceptors 94 -- IV Role of Voltage-Gated Sodium and Potassium Channels in Peripheral Sensitization 97 -- Chapter 4 TRPV1: A Polymodal Sensor in the Nociceptor Terminal / Michael J. Caterina, Una Park -- I Discovery and Cloning of the Vanilloid Receptor 114 -- II TRPV1 Exhibits a Highly Specific Expression Pattern 119 -- III Activators and Inhibitors of TRPV1 120 -- IV Regulation of TRPV1 127 -- V Contributions of TRPV1 to Acute Nociception and Hyperalgesia 134 -- Chapter 5 Nociceptive Signals to TRPV1 and its Clinical Potential / Uhtaek Oh -- II Endogenous Activators of TRPV1 156 -- III TRPV1 Ligand-Binding Sites 161 -- IV Nociceptive Signals to TRPV1 164 -- V TRPV1 Antagonists: A New Class of Analgesics 169 -- Chapter 6 Gating, Sensitization, and Desensitization of TRPV1 / Makoto Tominaga -- III Gating Properties of TRPV1 183 -- IV Sensitization of TRPV1 187 -- V Desensitization of TRPV1 191 -- Chapter 7 TRP Channels as Thermosensors / Stuart Bevan -- III TRPV1 is a Noxious Heat Sensor 202 -- IV TRPV2 210 -- V TRPV3 and TRPV4 Act as Warm Receptors 212 -- VI Cold Activated Ion Channels 222 -- VII TRP Channels as Invertebrate Thermosensors 228 -- Chapter 8 Acid Sensing Ionic Channels / Michaela Kress, Rainer Waldmann -- III Native Proton-Gated Cation Channels in Sensory Neurons 243 -- IV Cloned ASICs 245 -- V Properties of Cloned ASICs 247 -- VI ASIC Transcripts, Protein, and Currents in Sensory Neurons 259 -- VII Role of ASICs in Nociception 261 -- Chapter 9 P2X Receptors in Sensory Neurons / Makoto Tsuda, Kazuhide Inoue -- III Molecular Structure and Pharmacological Profiles of P2X Receptors 279 -- IV Electrophysiological Responses Following the Activation of P2X Receptors in Sensory Neurons 281 -- V Distribution of P2X Receptors in Sensory Neurons 284 -- VI P2X Receptors at Central and Peripheral Terminals 286 -- VII Activating P2X Receptors Causes and Modulates Pain Sensation 289 -- VIII Persistent Peripheral Inflammation Enhances P2X Receptor Expression and their Function, thereby Causing Pain 291 -- IX P2X Receptors in Sensory Neurons Have Crucial Roles in Neuropathic Pain 294 -- X P2X[subscript 4] Receptors in Spinal Microglia are Essential for Neuropathic Pain 299 -- Chapter 10 Voltage-Gated Sodium Channels and Neuropathic Pain / Kyungsoon Chung, Jin Mo Chung -- III Structure of VGSCs 313 -- IV Subtypes of VGSCs and Sodium Currents in Sensory Neurons 313 -- V TTXs VGSCs are Important for Ectopic Discharges and Neuropathic Pain 315 -- VI NA[subscript v]1.3 VGSC May be the Critical Subtype for Ectopic Discharge Generation 315 -- VII Involvement of TTXr VGSCs in Neuropathic Pain 317 -- Chapter 11 Voltage-Gated Potassium Channels in Sensory Neurons / Matthew N. Rasband, James S. Trimmer -- III Nociceptor Excitability 326 -- IV Basics of K[subscript v] Channels 326 -- V Classes of Native K[subscript v] Currents 327 -- VI Native K[subscript v] Channels in Nociceptive Neurons 329 -- VII Changes in K[subscript v] Currents and Pain 333 -- VIII K[subscript v] Channel Gene Expression in Sensory Neurons 335 -- IX Analyses of K[subscript v] Channel Protein Expression in Nociceptive Neurons 337 -- X K[subscript v]1 Channel Subunits and Subunit Combinations Define Distinct Populations of Sensory Neurons 340 -- XI K[subscript v] Channel Localization in Sensory Neurons 343 -- XII K[subscript v] Channels and Nerve Injury 344 -- XIII Genetic Intervention in K[subscript v] Channel Expression 345 -- Chapter 12 Two-Pore Domain Potassium Channels in Sensory Transduction / Donghee Kim -- III K[subscript 2P] Channel Family 355 -- IV Expression of K[subscript 2P] Channels in Sensory Neurons 361 -- V Functional Properties of K[subscript 2P] Channels 361 -- Chapter 13 Finding Sensory Neuron Mechanotransduction Components / Regina Bonsch, Gary R. Lewin -- III Mechanical Nociceptors and Other Relevant Mechanoreceptors 380 -- IV Physiology of Transduction 383 -- V Molecular Identity of the Transducer 385 -- VI Identification of Molecules Required for Vertebrate Sensory Mechanotransduction 390 -- VII Candidate Gene Approaches 391 -- VIII Are There Vertebrate mec Genes Involved in Sensory Mechanotransduction? 391 -- IX Are TRP Channels Candidates for the Sensory Neuron Mechanotransducer? 395 -- X Expression Cloning 398 -- XI Imaging Mechanotransduction with Fluorescent Dyes 400 -- XII Using DNA Microarrays to Find Transduction Components 400 -- XIII Biochemical Approaches 404 -- Chapter 14 Functional Diversity of Voltage-Dependent Ca[superscript 2+] Channels in Nociception: Recent Progress in Genetic Studies / Hee-Sup Shin, Chanki Kim, Daesoo Kim, Soonwook Choi -- III VDCC Family 417 -- Chapter 15 Expression Patterns and Histological Aspects of TRP Channels in Sensory Neurons / Tetsuo Fukuoka, Koichi Noguchi -- II TRPV1 (VR1) 440 -- III TRPV2 (VRL1) 446 -- IV TRPV3 (Also Known as VRL3) 447 -- V TRPV4 (Also Known as VRL-2/OTRPC4/VR-OAC/TRP12) 447 -- VI TRPM8 (Also Known as CMR1) 448 -- VII TRPA1 (Renamed from ANKTM1) 448.
Other author Oh, Uhtaek.
Subject Nociceptors.
Membranes (Biology) -- Research.
ISBN 0121533573